Human Gene IFNL1 (uc002okv.3) Description and Page Index
Description: Homo sapiens interferon, lambda 1 (IFNL1), mRNA. RefSeq Summary (NM_172140): This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 28B (IL28B) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY129150.1, BC117482.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1966682, SAMEA1968832 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000333625.3/ ENSP00000329991.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chr19:39,786,965-39,789,312 Size: 2,348 Total Exon Count: 5 Strand: + Coding Region Position: hg19 chr19:39,787,062-39,789,156 Size: 2,095 Coding Exon Count: 5
ID:IL29_HUMAN DESCRIPTION: RecName: Full=Interleukin-29; Short=IL-29; AltName: Full=Cytokine Zcyto21; AltName: Full=Interferon lambda-1; Short=IFN-lambda-1; Flags: Precursor; FUNCTION: Cytokine with immunomodulatory activity. May play a role in antiviral immunity. Up-regulates MHC class I antigen expression. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway. SUBCELLULAR LOCATION: Secreted. INDUCTION: By viral infections or double-stranded RNA. SIMILARITY: Belongs to the IL-28/IL-29 family. WEB RESOURCE: Name=Wikipedia; Note=Interleukin-29 entry; URL="http://en.wikipedia.org/wiki/Interleukin_29";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8IU54
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Biological Process: GO:0002829 negative regulation of type 2 immune response GO:0007259 JAK-STAT cascade GO:0008285 negative regulation of cell proliferation GO:0010469 regulation of receptor activity GO:0019221 cytokine-mediated signaling pathway GO:0032696 negative regulation of interleukin-13 production GO:0032714 negative regulation of interleukin-5 production GO:0032729 positive regulation of interferon-gamma production GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein GO:0043381 negative regulation of memory T cell differentiation GO:0045087 innate immune response GO:0045345 positive regulation of MHC class I biosynthetic process GO:0045581 negative regulation of T cell differentiation GO:0045892 negative regulation of transcription, DNA-templated GO:0045893 positive regulation of transcription, DNA-templated GO:0046427 positive regulation of JAK-STAT cascade GO:0050778 positive regulation of immune response GO:0051607 defense response to virus