ID:SRTD1_HUMAN DESCRIPTION: RecName: Full=SERTA domain-containing protein 1; AltName: Full=CDK4-binding protein p34SEI1; Short=SEI-1; AltName: Full=Transcriptional regulator interacting with the PHD-bromodomain 1; Short=TRIP-Br1; FUNCTION: Acts at E2F-responsive promoters to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. Stimulates E2F-1/DP-1 transcriptional activity. Renders the activity of cyclin D1/CDK4 resistant to the inhibitory effects of p16(INK4a). SUBUNIT: Interacts with the PHD-bromodomain of TIF1, TRIM28/TIF1B and p300/CBP. Binds to DP1. Also interacts with CDK4. INTERACTION: Q8WTS6:SETD7; NbExp=2; IntAct=EBI-748601, EBI-1268586; SIMILARITY: Contains 1 SERTA domain. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/sei1/";
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): SERTAD1 CDC HuGE Published Literature: SERTAD1
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UHV2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0008284 positive regulation of cell proliferation GO:0045893 positive regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter