Human Gene SERTAD1 (uc002ont.4) Description and Page Index
  Description: Homo sapiens SERTA domain containing 1 (SERTAD1), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr19:40,928,409-40,931,932 Size: 3,524 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg19 chr19:40,928,743-40,929,453 Size: 711 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr19:40,928,409-40,931,932)mRNA (may differ from genome)Protein (236 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=SERTA domain-containing protein 1; AltName: Full=CDK4-binding protein p34SEI1; Short=SEI-1; AltName: Full=Transcriptional regulator interacting with the PHD-bromodomain 1; Short=TRIP-Br1;
FUNCTION: Acts at E2F-responsive promoters to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. Stimulates E2F-1/DP-1 transcriptional activity. Renders the activity of cyclin D1/CDK4 resistant to the inhibitory effects of p16(INK4a).
SUBUNIT: Interacts with the PHD-bromodomain of TIF1, TRIM28/TIF1B and p300/CBP. Binds to DP1. Also interacts with CDK4.
INTERACTION: Q8WTS6:SETD7; NbExp=2; IntAct=EBI-748601, EBI-1268586;
SIMILARITY: Contains 1 SERTA domain.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): SERTAD1
CDC HuGE Published Literature: SERTAD1

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D000082 Acetaminophen
  • D016604 Aflatoxin B1
  • D001564 Benzo(a)pyrene
  • D003993 Dibutyl Phthalate
  • C517041 (4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)
  • C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl
  • C016403 2,4-dinitrotoluene
  • D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
  • C553817 7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one
  • C547126 AZM551248
          more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 15.38 RPKM in Lung
Total median expression: 358.96 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -61.30159-0.386 Picture PostScript Text
3' UTR -127.01334-0.380 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009263 - SERTA

Pfam Domains:
PF06031 - SERTA motif

ModBase Predicted Comparative 3D Structure on Q9UHV2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 Protein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0008284 positive regulation of cell proliferation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm

-  Descriptions from all associated GenBank mRNAs
  AK074652 - Homo sapiens cDNA FLJ90171 fis, clone MAMMA1000403, highly similar to SERTA domain-containing protein 1.
BC002670 - Homo sapiens SERTA domain containing 1, mRNA (cDNA clone MGC:3465 IMAGE:3613213), complete cds.
AF366402 - Homo sapiens TRIP-Br1 mRNA, complete cds.
LF207571 - JP 2014500723-A/15074: Polycomb-Associated Non-Coding RNAs.
AF117959 - Homo sapiens CDK4-binding protein p34SEI1 (SEI1) mRNA, complete cds.
LF367197 - JP 2014500723-A/174700: Polycomb-Associated Non-Coding RNAs.
JD349204 - Sequence 330228 from Patent EP1572962.
AK222970 - Homo sapiens mRNA for SERTA domain containing 1 variant, clone: HSI02080.
AK223011 - Homo sapiens mRNA for SERTA domain containing 1 variant, clone: HSI13949.
JD219817 - Sequence 200841 from Patent EP1572962.
JD054675 - Sequence 35699 from Patent EP1572962.
JD520780 - Sequence 501804 from Patent EP1572962.
JD363663 - Sequence 344687 from Patent EP1572962.
JD041964 - Sequence 22988 from Patent EP1572962.
KJ893721 - Synthetic construct Homo sapiens clone ccsbBroadEn_03115 SERTAD1 gene, encodes complete protein.
DQ892993 - Synthetic construct clone IMAGE:100005623; FLH191477.01X; RZPDo839D0877D SERTA domain containing 1 (SERTAD1) gene, encodes complete protein.
DQ896241 - Synthetic construct Homo sapiens clone IMAGE:100010701; FLH191473.01L; RZPDo839D0867D SERTA domain containing 1 (SERTAD1) gene, encodes complete protein.
AB464704 - Synthetic construct DNA, clone: pF1KB9587, Homo sapiens SERTAD1 gene for SERTA domain containing 1, without stop codon, in Flexi system.
JD022811 - Sequence 3835 from Patent EP1572962.
JD212008 - Sequence 193032 from Patent EP1572962.
LF367195 - JP 2014500723-A/174698: Polycomb-Associated Non-Coding RNAs.
JD021608 - Sequence 2632 from Patent EP1572962.
JD036203 - Sequence 17227 from Patent EP1572962.
JD297770 - Sequence 278794 from Patent EP1572962.
MA602774 - JP 2018138019-A/174700: Polycomb-Associated Non-Coding RNAs.
MA602772 - JP 2018138019-A/174698: Polycomb-Associated Non-Coding RNAs.
MA443148 - JP 2018138019-A/15074: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_013376, NP_037508, Q9BUE7, Q9UHV2, SEI1, SRTD1_HUMAN
UCSC ID: uc002ont.4
RefSeq Accession: NM_013376
Protein: Q9UHV2 (aka SRTD1_HUMAN or STD1_HUMAN)
CCDS: CCDS12557.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_013376.3
exon count: 2CDS single in 3' UTR: no RNA size: 1213
ORF size: 711CDS single in intron: no Alignment % ID: 99.92
txCdsPredict score: 1568.00frame shift in genome: no % Coverage: 99.26
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.