Human Gene BOLA1 (uc001etf.3) Description and Page Index
  Description: Homo sapiens bolA homolog 1 (E. coli) (BOLA1), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr1:149,871,155-149,872,348 Size: 1,194 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg19 chr1:149,871,613-149,872,026 Size: 414 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:149,871,155-149,872,348)mRNA (may differ from genome)Protein (137 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
OMIMPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=BolA-like protein 1; AltName: Full=hBolA;
SUBCELLULAR LOCATION: Secreted. Note=Could be secreted via a non- classical export pathway.
TISSUE SPECIFICITY: Widely expressed.
SIMILARITY: Belongs to the bolA/yrbA family.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): BOLA1
CDC HuGE Published Literature: BOLA1

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 12.13 RPKM in Esophagus - Muscularis
Total median expression: 427.79 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -46.10121-0.381 Picture PostScript Text
3' UTR -98.60322-0.306 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002634 - BolA

Pfam Domains:
PF01722 - BolA-like protein

SCOP Domains:
82657 - BolA-like

ModBase Predicted Comparative 3D Structure on Q9Y3E2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
 Gene Details    
 Gene Sorter    
 Protein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0005515 protein binding

Biological Process:
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005739 mitochondrion

-  Descriptions from all associated GenBank mRNAs
  AK313014 - Homo sapiens cDNA, FLJ93480, Homo sapiens CGI-143 protein (CGI-143), mRNA.
BC002771 - Homo sapiens bolA homolog 1 (E. coli), mRNA (cDNA clone IMAGE:3617333).
BC063405 - Homo sapiens bolA homolog 1 (E. coli), mRNA (cDNA clone MGC:75015 IMAGE:5190565), complete cds.
AF151901 - Homo sapiens CGI-143 protein mRNA, complete cds.
CU687694 - Synthetic construct Homo sapiens gateway clone IMAGE:100021516 5' read BOLA1 mRNA.
HQ448632 - Synthetic construct Homo sapiens clone IMAGE:100072071; CCSB012086_02 bolA homolog 1 (E. coli) (BOLA1) gene, encodes complete protein.
KJ893785 - Synthetic construct Homo sapiens clone ccsbBroadEn_03179 BOLA1 gene, encodes complete protein.
DQ576840 - Homo sapiens piRNA piR-44952, complete sequence.
JD420300 - Sequence 401324 from Patent EP1572962.
JD285880 - Sequence 266904 from Patent EP1572962.
JD402372 - Sequence 383396 from Patent EP1572962.
JD101444 - Sequence 82468 from Patent EP1572962.
JD049963 - Sequence 30987 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B2R7K2, BOLA1_HUMAN, CGI-143, D3DUZ4, NM_016074, NP_057158, Q5QNY0, Q9Y3E2
UCSC ID: uc001etf.3
RefSeq Accession: NM_016074
Protein: Q9Y3E2 (aka BOLA1_HUMAN)

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_016074.3
exon count: 2CDS single in 3' UTR: no RNA size: 872
ORF size: 414CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 938.00frame shift in genome: no % Coverage: 98.28
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.