Human Gene RRAGC (uc001ccq.3) Description and Page Index
Description: Homo sapiens Ras-related GTP binding C (RRAGC), transcript variant 1, mRNA. RefSeq Summary (NM_022157): This gene encodes a member of the GTR/RAG GTP-binding protein family. The encoded protein is a monomeric guanine nucleotide-binding protein which forms a heterodimer with RRAGA and RRAGB and is primarily localized to the cytoplasm. The encoded protein promotes intracellular localization of the mTOR complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]. Transcript (Including UTRs) Position: hg19 chr1:39,303,869-39,325,495 Size: 21,627 Total Exon Count: 7 Strand: - Coding Region Position: hg19 chr1:39,305,225-39,325,318 Size: 20,094 Coding Exon Count: 7
ID:RRAGC_HUMAN DESCRIPTION: RecName: Full=Ras-related GTP-binding protein C; Short=Rag C; Short=RagC; AltName: Full=GTPase-interacting protein 2; AltName: Full=TIB929; FUNCTION: Has guanine nucleotide-binding activity but weak intrinsic GTPase activity. Probably required for the amino acid- induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. SUBUNIT: Binds GTP. Forms a heterodimer with RRAGA, in a sequence- independent manner, and RRAGB. Heterodimerization stabilizes PPAG proteins. In complex with RRAGA or RRAGB, interacts with RPTOR; this interaction is particularly efficient with GTP-loaded RRAGB and GDP-loaded RRAGC. It is regulated by amino acids, since amino acid stimulation of cells increase the GTP-loading of RRAGB. Interacts with NOL8. INTERACTION: Q7L523:RRAGA; NbExp=11; IntAct=EBI-752390, EBI-752376; Q5VZM2:RRAGB; NbExp=4; IntAct=EBI-752390, EBI-993049; SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Lysosome. Note=Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state of associated RRAGA. SIMILARITY: Belongs to the GTR/RAG GTP-binding protein family. SEQUENCE CAUTION: Sequence=BAB14548.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9HB90
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.