Human Gene ZNF268 (uc010tcf.2) Description and Page Index
  Description: Homo sapiens zinc finger protein 268 (ZNF268), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr12:133,757,995-133,783,697 Size: 25,703 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr12:133,758,584-133,781,116 Size: 22,533 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:133,757,995-133,783,697)mRNA (may differ from genome)Protein (947 aa)
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-  Comments and Description Text from UniProtKB
  ID: ZN268_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 268; AltName: Full=Zinc finger protein HZF3;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Probable).
DEVELOPMENTAL STAGE: Highly expressed in 3- to 5-week-old embryos.
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 24 C2H2-type zinc fingers.
SIMILARITY: Contains 1 KRAB domain.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): ZNF268
CDC HuGE Published Literature: ZNF268
Positive Disease Associations: Erythrocytes
Related Studies:
  1. Erythrocytes
    , , . [PubMed 0]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1.15 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 15.38 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -120.00330-0.364 Picture PostScript Text
3' UTR -647.422581-0.251 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF01352 - KRAB box
PF13894 - C2H2-type zinc finger
PF13912 - C2H2-type zinc finger

SCOP Domains:
48695 - Multiheme cytochromes
109640 - KRAB domain (Kruppel-associated box, Pfam 01352)
57667 - C2H2 and C2HC zinc fingers

Protein Data Bank (PDB) 3-D Structure
MuPIT help

2EL4
- NMR MuPIT

2EL5
- NMR MuPIT

2EL6
- NMR MuPIT
To conserve bandwidth, only the images from the first 3 structures are shown.
2EM1 - NMR MuPIT 2EMV - NMR MuPIT 2EMW - NMR MuPIT
2EMX - NMR MuPIT 2EMY - NMR MuPIT 2EN0 - NMR MuPIT
2EN6 - NMR MuPIT 2EN7 - NMR MuPIT 2EOF - NMR MuPIT
2EOG - NMR MuPIT 2EOI - NMR MuPIT 2EOJ - NMR MuPIT
2EOK - NMR MuPIT 2EOL - NMR MuPIT 2EOP - NMR MuPIT
2EPV - NMR MuPIT 2EPW - NMR MuPIT 2EPY - NMR MuPIT
2YTF - NMR MuPIT 2YTQ - NMR MuPIT


ModBase Predicted Comparative 3D Structure on Q14587
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001934 positive regulation of protein phosphorylation
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007346 regulation of mitotic cell cycle
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0030154 cell differentiation
GO:0030335 positive regulation of cell migration
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043497 regulation of protein heterodimerization activity
GO:0045597 positive regulation of cell differentiation
GO:0045732 positive regulation of protein catabolic process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0071157 negative regulation of cell cycle arrest
GO:0071356 cellular response to tumor necrosis factor
GO:0090073 positive regulation of protein homodimerization activity
GO:1901224 positive regulation of NIK/NF-kappaB signaling

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0015629 actin cytoskeleton


-  Descriptions from all associated GenBank mRNAs
  AK302159 - Homo sapiens cDNA FLJ51381 complete cds, highly similar to Zinc finger protein 268.
AF317549 - Homo sapiens zinc finger protein 268 (ZNF268) mRNA, complete cds.
BC110542 - Homo sapiens zinc finger protein 268, mRNA (cDNA clone MGC:126498 IMAGE:40036577), complete cds.
AK027712 - Homo sapiens cDNA FLJ14806 fis, clone NT2RP4001753, highly similar to Zinc finger protein 268.
AF432217 - Homo sapiens CLL-associated antigen KW-4 splice variant 2 mRNA, complete cds; alternatively spliced.
BC058548 - Homo sapiens cDNA clone IMAGE:5445456, partial cds.
AF141655 - Homo sapiens telomeric-associated zinc finger protein mRNA, partial cds.
AF385187 - Homo sapiens ZNF268B mRNA, complete cds, alternatively spliced.
AY583691 - Homo sapiens zinc finger protein 268 variant C (ZNF268) mRNA, complete sequence.
JD290972 - Sequence 271996 from Patent EP1572962.
JD027294 - Sequence 8318 from Patent EP1572962.
DQ057359 - Homo sapiens ZNF268f mRNA, partial sequence.
DQ057360 - Homo sapiens ZNF268g mRNA, partial sequence.
DQ057356 - Homo sapiens ZNF268c mRNA, partial sequence.
DQ057357 - Homo sapiens ZNF268d mRNA, partial sequence.
DQ057358 - Homo sapiens ZNF268e mRNA, partial sequence.
DQ057361 - Homo sapiens ZNF268b2 mRNA, partial sequence.
JD446704 - Sequence 427728 from Patent EP1572962.
JD290847 - Sequence 271871 from Patent EP1572962.
JD029991 - Sequence 11015 from Patent EP1572962.
JD227296 - Sequence 208320 from Patent EP1572962.
KJ898289 - Synthetic construct Homo sapiens clone ccsbBroadEn_07683 ZNF268 gene, encodes complete protein.
JD023892 - Sequence 4916 from Patent EP1572962.
JD028004 - Sequence 9028 from Patent EP1572962.
JD314870 - Sequence 295894 from Patent EP1572962.
JD434510 - Sequence 415534 from Patent EP1572962.
JD314870 - Sequence 295894 from Patent EP1572962.
X78926 - H.sapiens HZF3 mRNA for zinc finger protein.
JD137580 - Sequence 118604 from Patent EP1572962.
JD041026 - Sequence 22050 from Patent EP1572962.
JD312302 - Sequence 293326 from Patent EP1572962.
JD285678 - Sequence 266702 from Patent EP1572962.
JD238735 - Sequence 219759 from Patent EP1572962.
JD342739 - Sequence 323763 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q14587 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: NM_003415, NP_001159354, Q14587, Q96RH4, Q9BZJ9, ZN268_HUMAN
UCSC ID: uc010tcf.2
RefSeq Accession: NM_003415
Protein: Q14587 (aka ZN268_HUMAN or Z268_HUMAN)
CCDS: CCDS45012.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_003415.2
exon count: 6CDS single in 3' UTR: no RNA size: 5756
ORF size: 2844CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 5271.50frame shift in genome: no % Coverage: 99.98
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: yes # AT/AC introns 0
selenocysteine: no end bleed into intron: 2812# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.