Human Gene ARL17A (uc002iks.2) Description and Page Index
  Description: Homo sapiens ADP-ribosylation factor-like 17A (ARL17A), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr17:44,630,122-44,657,088 Size: 26,967 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr17:44,634,722-44,653,688 Size: 18,967 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr17:44,630,122-44,657,088)mRNA (may differ from genome)Protein (177 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
PubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=ADP-ribosylation factor-like protein 17; AltName: Full=ADP-ribosylation factor 7 variant;
FUNCTION: GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus (By similarity).
SUBCELLULAR LOCATION: Golgi apparatus (By similarity).
SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
SEQUENCE CAUTION: Sequence=AAF64278.1; Type=Frameshift; Positions=114; Sequence=AAF69643.1; Type=Frameshift; Positions=17; Sequence=AAH30570.1; Type=Erroneous initiation; Sequence=BAD92581.1; Type=Erroneous initiation;

-  MalaCards Disease Associations
  MalaCards Gene Search: ARL17A
Diseases sorted by gene-association score: retinitis pigmentosa (0)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.68 RPKM in Prostate
Total median expression: 20.27 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -44.70139-0.322 Picture PostScript Text
3' UTR -1539.534600-0.335 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR024156 - Small_GTPase_ARF
IPR006689 - Small_GTPase_ARF/SAR

Pfam Domains:
PF00025 - ADP-ribosylation factor family
PF15840 - ADP-ribosylation factor-like protein 17

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases

ModBase Predicted Comparative 3D Structure on Q8IVW1
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 Protein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0005525 GTP binding

Biological Process:
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport

Cellular Component:
GO:0005622 intracellular
GO:0005794 Golgi apparatus

-  Descriptions from all associated GenBank mRNAs
  AF208864 - Homo sapiens ARF mRNA, complete cds.
AF119889 - Homo sapiens PRO2667 mRNA, complete cds.
BC071681 - Homo sapiens ADP-ribosylation factor-like protein, mRNA (cDNA clone IMAGE:3907731).
BT007332 - Homo sapiens NBR2 mRNA, complete cds.
KJ904753 - Synthetic construct Homo sapiens clone ccsbBroadEn_14147 ARL17A gene, encodes complete protein.
AB209344 - Homo sapiens mRNA for ADP-ribosylation factor 7 variant protein.
BX537922 - Homo sapiens mRNA; cDNA DKFZp686A05147 (from clone DKFZp686A05147).
AK094908 - Homo sapiens cDNA FLJ37589 fis, clone BRCOC2006243.
BX647266 - Homo sapiens mRNA; cDNA DKFZp686J1482 (from clone DKFZp686J1482).
JD379774 - Sequence 360798 from Patent EP1572962.
JD120607 - Sequence 101631 from Patent EP1572962.
JD367515 - Sequence 348539 from Patent EP1572962.
DQ573719 - Homo sapiens piRNA piR-41831, complete sequence.
DQ601382 - Homo sapiens piRNA piR-39448, complete sequence.
DQ589362 - Homo sapiens piRNA piR-56474, complete sequence.
DQ573434 - Homo sapiens piRNA piR-41546, complete sequence.
DQ574245 - Homo sapiens piRNA piR-42357, complete sequence.
BC041803 - Homo sapiens ADP-ribosylation factor-like 17 pseudogene 1, mRNA (cDNA clone MGC:41814 IMAGE:5303659), complete cds.
BC030570 - Homo sapiens ADP-ribosylation factor-like 17, mRNA (cDNA clone MGC:45095 IMAGE:5518676), complete cds.
AK289590 - Homo sapiens cDNA FLJ76374 complete cds, highly similar to Homo sapiens ADP-ribosylation factor-like 17 pseudogene 1, mRNA.
AK315857 - Homo sapiens cDNA, FLJ79506 complete cds, highly similar to ADP-ribosylation factor-like protein 14.
DQ593659 - Homo sapiens piRNA piR-33771, complete sequence.
KJ902581 - Synthetic construct Homo sapiens clone ccsbBroadEn_11975 ARL17A gene, encodes complete protein.
JD358948 - Sequence 339972 from Patent EP1572962.
BC020869 - Homo sapiens cDNA clone IMAGE:4606677.

-  Other Names for This Gene
  Alternate Gene Symbols: ARF1P2, ARL17B, ARL17P1, ARL17_HUMAN, B0AZR6, NM_001113738, NP_001107210, PRO2667, Q59FW5, Q8IVW1, Q8N6E2, Q8TD73, Q8WW54, Q9NZD5, Q9P158
UCSC ID: uc002iks.2
RefSeq Accession: NM_001113738
Protein: Q8IVW1 (aka ARL17_HUMAN)
CCDS: CCDS45718.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_001113738.1
exon count: 4CDS single in 3' UTR: no RNA size: 5273
ORF size: 534CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 974.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 5
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.