Description: Homo sapiens fibroblast growth factor 7 (FGF7), mRNA. RefSeq Summary (NM_002009): The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from transcript and genomic sequence to make the sequence consistent with the reference genome assembly. The extent of this RefSeq transcript is supported by transcript alignments. Transcript (Including UTRs) Position: hg19 chr15:49,715,375-49,779,523 Size: 64,149 Total Exon Count: 4 Strand: + Coding Region Position: hg19 chr15:49,716,495-49,776,701 Size: 60,207 Coding Exon Count: 3
ID:FGF7_HUMAN DESCRIPTION: RecName: Full=Fibroblast growth factor 7; Short=FGF-7; AltName: Full=Heparin-binding growth factor 7; Short=HBGF-7; AltName: Full=Keratinocyte growth factor; Flags: Precursor; FUNCTION: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation. SUBUNIT: Interacts with FGFBP1. Interacts with FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Epithelial cell. SIMILARITY: Belongs to the heparin-binding growth factors family.
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Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): FGF7 CDC HuGE Published Literature: FGF7 Positive Disease Associations: Goiter Related Studies:
Goiter Alexander Teumer et al. American journal of human genetics 2011, Genome-wide association study identifies four genetic loci associated with thyroid volume and goiter risk., American journal of human genetics.
[PubMed 21565293]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P21781
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
