Description: Homo sapiens small nuclear RNA activating complex, polypeptide 5, 19kDa (SNAPC5), mRNA. RefSeq Summary (NM_006049): This gene encodes a subunit of the small nuclear RNA (snRNA)-activating protein complex that plays a role in the transcription of snRNA genes. This complex binds to the promoters of snRNA genes transcribed by either RNA polymerase II or III and recruits other regulatory factors to activate snRNA gene transcription. The encoded protein may play a role in stabilizing this complex. A pseudogene of this gene has been identified on chromosome 6. [provided by RefSeq, Jul 2016]. Transcript (Including UTRs) Position: hg19 chr15:66,782,666-66,790,146 Size: 7,481 Total Exon Count: 4 Strand: - Coding Region Position: hg19 chr15:66,786,774-66,790,069 Size: 3,296 Coding Exon Count: 3
ID:SNPC5_HUMAN DESCRIPTION: RecName: Full=snRNA-activating protein complex subunit 5; Short=SNAPc subunit 5; AltName: Full=Small nuclear RNA-activating complex polypeptide 5; AltName: Full=snRNA-activating protein complex 19 kDa subunit; Short=SNAPc 19 kDa subunit; FUNCTION: Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. SUBUNIT: Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC5 interacts with SNAPC4. SUBCELLULAR LOCATION: Nucleus.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O75971
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0006384 transcription initiation from RNA polymerase III promoter GO:0042795 snRNA transcription from RNA polymerase II promoter
BC066984 - Homo sapiens cDNA clone IMAGE:4826623. LF384557 - JP 2014500723-A/192060: Polycomb-Associated Non-Coding RNAs. AK024763 - Homo sapiens cDNA: FLJ21110 fis, clone CAS05377. AK292051 - Homo sapiens cDNA FLJ76570 complete cds, highly similar to Homo sapiens small nuclear RNA activating complex, polypeptide 5, 19kDa, mRNA. BC014315 - Homo sapiens small nuclear RNA activating complex, polypeptide 5, 19kDa, mRNA (cDNA clone MGC:22700 IMAGE:3997264), complete cds. AF093593 - Homo sapiens snRNA activating protein complex 19kDa subunit (SNAP19) mRNA, complete cds. AK312018 - Homo sapiens cDNA, FLJ92293. KJ904649 - Synthetic construct Homo sapiens clone ccsbBroadEn_14043 SNAPC5 gene, encodes complete protein. AB464224 - Synthetic construct DNA, clone: pF1KB7505, Homo sapiens SNAPC5 gene for small nuclear RNA activating complex, polypeptide 5, 19kDa, without stop codon, in Flexi system. LF377480 - JP 2014500723-A/184983: Polycomb-Associated Non-Coding RNAs. MA620134 - JP 2018138019-A/192060: Polycomb-Associated Non-Coding RNAs. MA613057 - JP 2018138019-A/184983: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein O75971 (Reactome details) participates in the following event(s):
R-HSA-83791 Binding of SNAPc, Oct-1, and Staf to Type 3 Promoter R-HSA-6810239 SNAPc binds PSE of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) R-HSA-83793 Binding of TFIIIB to SNAPc:Oct-1:Staf:Type 3 Promoter Complex R-HSA-112054 RNA Polymerase III Abortive Initiation At Type 3 Open Promoters R-HSA-112156 RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters R-HSA-112152 RNA Polymerase III Promoter Opening at Type 3 Promoters R-HSA-6810234 General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene R-HSA-83803 Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex R-HSA-6810233 CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter R-HSA-6810238 RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) R-HSA-6810235 RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain R-HSA-6814885 CBCAP complex binds 7-methylguanosine cap of snRNA R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-6807505 RNA polymerase II transcribes snRNA genes R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation R-HSA-76046 RNA Polymerase III Transcription Initiation R-HSA-73857 RNA Polymerase II Transcription R-HSA-74158 RNA Polymerase III Transcription R-HSA-74160 Gene expression (Transcription)
US Server
