Human Gene NAA35 (uc004aoi.4) Description and Page Index
  Description: Homo sapiens N(alpha)-acetyltransferase 35, NatC auxiliary subunit (NAA35), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr9:88,556,057-88,637,217 Size: 81,161 Total Exon Count: 23 Strand: +
Coding Region
   Position: hg19 chr9:88,557,075-88,636,875 Size: 79,801 Coding Exon Count: 22 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr9:88,556,057-88,637,217)mRNA (may differ from genome)Protein (725 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtPubMedReactomeStanford SOURCETreefamUniProtKB
Wikipedia

-  Comments and Description Text from UniProtKB
  ID: NAA35_HUMAN
DESCRIPTION: RecName: Full=N-alpha-acetyltransferase 35, NatC auxiliary subunit; AltName: Full=Embryonic growth-associated protein homolog; AltName: Full=Protein MAK10 homolog;
FUNCTION: Regulates proliferation of smooth muscle cells (By similarity). Component of the N-terminal acetyltransferase C (NatC) complex which may catalyze acetylation of N-terminal methionine residues.
SUBUNIT: Interacts with NAA50 (By similarity). Component of the N- terminal acetyltransferase C (NatC) complex, which is composed of NAA35, LSMD1 and NAA30.
SUBCELLULAR LOCATION: Cytoplasm.
SIMILARITY: Belongs to the MAK10 family.
SEQUENCE CAUTION: Sequence=BAB15097.1; Type=Frameshift; Positions=518; Sequence=BAB15435.1; Type=Erroneous initiation;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 13.43 RPKM in Testis
Total median expression: 275.98 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -60.50137-0.442 Picture PostScript Text
3' UTR -81.70342-0.239 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007244 - NatC_AcTrfase_Mak10

Pfam Domains:
PF04112 - Mak10 subunit, NatC N(alpha)-terminal acetyltransferase

ModBase Predicted Comparative 3D Structure on Q5VZE5
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004596 peptide alpha-N-acetyltransferase activity
GO:0005515 protein binding

Biological Process:
GO:0006474 N-terminal protein amino acid acetylation
GO:0043066 negative regulation of apoptotic process
GO:0048659 smooth muscle cell proliferation

Cellular Component:
GO:0005737 cytoplasm
GO:0031417 NatC complex
GO:0005844 polysome


-  Descriptions from all associated GenBank mRNAs
  AK292239 - Homo sapiens cDNA FLJ77588 complete cds, highly similar to Homo sapiens MAK10 homolog, amino-acid N-acetyltransferase subunit, (S. cerevisiae) (MAK10), mRNA.
AK225237 - Homo sapiens mRNA for corneal wound healing-related protein variant, clone: COL07381.
AK025266 - Homo sapiens cDNA: FLJ21613 fis, clone COL07381.
BC117427 - Homo sapiens MAK10 homolog, amino-acid N-acetyltransferase subunit (S. cerevisiae), mRNA (cDNA clone MGC:151036 IMAGE:40125978), complete cds.
BC117429 - Homo sapiens MAK10 homolog, amino-acid N-acetyltransferase subunit (S. cerevisiae), mRNA (cDNA clone MGC:151038 IMAGE:40125980), complete cds.
JD257173 - Sequence 238197 from Patent EP1572962.
JD218198 - Sequence 199222 from Patent EP1572962.
JD407337 - Sequence 388361 from Patent EP1572962.
JD211250 - Sequence 192274 from Patent EP1572962.
AK056059 - Homo sapiens cDNA FLJ31497 fis, clone NT2NE2005317, highly similar to Homo sapiens MAK10 homolog, amino-acid N-acetyltransferase subunit, (S. cerevisiae) (MAK10), mRNA.
AK026296 - Homo sapiens cDNA: FLJ22643 fis, clone HSI07031.
JD080058 - Sequence 61082 from Patent EP1572962.
JD109948 - Sequence 90972 from Patent EP1572962.
JD439356 - Sequence 420380 from Patent EP1572962.
JD095668 - Sequence 76692 from Patent EP1572962.
JD119198 - Sequence 100222 from Patent EP1572962.
LF324923 - JP 2014500723-A/132426: Polycomb-Associated Non-Coding RNAs.
JD564188 - Sequence 545212 from Patent EP1572962.
MA560500 - JP 2018138019-A/132426: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q5VZE5 (Reactome details) participates in the following event(s):

R-HSA-6814090 NatC acetylates ARFFRP1
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic
R-HSA-199991 Membrane Trafficking
R-HSA-5653656 Vesicle-mediated transport

-  Other Names for This Gene
  Alternate Gene Symbols: EGAP, MAK10, NAA35_HUMAN, NM_024635, NP_078911, Q5VZE5, Q9H631, Q9H703
UCSC ID: uc004aoi.4
RefSeq Accession: NM_024635
Protein: Q5VZE5 (aka NAA35_HUMAN)
CCDS: CCDS6673.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_024635.3
exon count: 23CDS single in 3' UTR: no RNA size: 2657
ORF size: 2178CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4492.50frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.