Human Gene NOL10 (uc002raq.3) Description and Page Index
  Description: Homo sapiens nucleolar protein 10 (NOL10), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr2:10,710,892-10,830,113 Size: 119,222 Total Exon Count: 21 Strand: -
Coding Region
   Position: hg19 chr2:10,712,197-10,829,987 Size: 117,791 Coding Exon Count: 21 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:10,710,892-10,830,113)mRNA (may differ from genome)Protein (688 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: NOL10_HUMAN
DESCRIPTION: RecName: Full=Nucleolar protein 10;
SUBCELLULAR LOCATION: Nucleus, nucleolus.
SIMILARITY: Belongs to the WD repeat NOL10/ENP2 family.
SIMILARITY: Contains 5 WD repeats.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.13 RPKM in Testis
Total median expression: 295.36 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -58.50126-0.464 Picture PostScript Text
3' UTR -383.701305-0.294 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR012580 - NUC153
IPR015943 - WD40/YVTN_repeat-like_dom
IPR001680 - WD40_repeat
IPR017986 - WD40_repeat_dom

Pfam Domains:
PF08159 - NUC153 domain

SCOP Domains:
50952 - Soluble quinoprotein glucose dehydrogenase
50960 - TolB, C-terminal domain
63829 - Calcium-dependent phosphotriesterase
69304 - Tricorn protease N-terminal domain
101898 - NHL repeat
101908 - Putative isomerase YbhE
50969 - YVTN repeat-like/Quinoprotein amine dehydrogenase
50974 - Nitrous oxide reductase, N-terminal domain
50978 - WD40 repeat-like
50993 - Prolyl oligopeptidase, N-terminal domain
69322 - Tricorn protease domain 2
50998 - Quinoprotein alcohol dehydrogenase-like
51004 - C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase

ModBase Predicted Comparative 3D Structure on Q9BSC4
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserGenome BrowserGenome Browser
Gene Details  Gene DetailsGene DetailsGene Details
Gene Sorter  Gene SorterGene SorterGene Sorter
  EnsemblFlyBaseWormBaseSGD
  Protein SequenceProtein SequenceProtein SequenceProtein Sequence
  AlignmentAlignmentAlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding

Cellular Component:
GO:0005634 nucleus
GO:0005730 nucleolus


-  Descriptions from all associated GenBank mRNAs
  AK024137 - Homo sapiens cDNA FLJ14075 fis, clone HEMBB1001905, weakly similar to TRICHOHYALIN.
BC005125 - Homo sapiens nucleolar protein 10, mRNA (cDNA clone MGC:10515 IMAGE:3841643), complete cds.
AK299617 - Homo sapiens cDNA FLJ53179 complete cds, highly similar to Nucleolar protein 10.
AK297169 - Homo sapiens cDNA FLJ54700 complete cds, highly similar to Nucleolar protein 10.
AK290680 - Homo sapiens cDNA FLJ76267 complete cds, highly similar to Homo sapiens nucleolar protein 10, mRNA.
KJ894756 - Synthetic construct Homo sapiens clone ccsbBroadEn_04150 NOL10 gene, encodes complete protein.
JD379577 - Sequence 360601 from Patent EP1572962.
JD493916 - Sequence 474940 from Patent EP1572962.
JD062997 - Sequence 44021 from Patent EP1572962.
JD332531 - Sequence 313555 from Patent EP1572962.
JD319080 - Sequence 300104 from Patent EP1572962.
JD382567 - Sequence 363591 from Patent EP1572962.
JD507433 - Sequence 488457 from Patent EP1572962.
JD197213 - Sequence 178237 from Patent EP1572962.
JD334630 - Sequence 315654 from Patent EP1572962.
JD428179 - Sequence 409203 from Patent EP1572962.
JD281140 - Sequence 262164 from Patent EP1572962.
JD323190 - Sequence 304214 from Patent EP1572962.
JD299412 - Sequence 280436 from Patent EP1572962.
JD234370 - Sequence 215394 from Patent EP1572962.
JD283167 - Sequence 264191 from Patent EP1572962.
AK024000 - Homo sapiens cDNA FLJ13938 fis, clone Y79AA1000824.
CU675005 - Synthetic construct Homo sapiens gateway clone IMAGE:100017772 5' read NOL10 mRNA.
BC037841 - Homo sapiens nucleolar protein 10, mRNA (cDNA clone IMAGE:4814644).
JD462597 - Sequence 443621 from Patent EP1572962.
JD538161 - Sequence 519185 from Patent EP1572962.
JD550688 - Sequence 531712 from Patent EP1572962.
JD256388 - Sequence 237412 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K3R5, NM_024894, NOL10_HUMAN, NP_079170, Q53RC9, Q96TA5, Q9BSC4, Q9H7Y7, Q9H855, uc002raq.2
UCSC ID: uc002raq.3
RefSeq Accession: NM_024894
Protein: Q9BSC4 (aka NOL10_HUMAN)
CCDS: CCDS1673.2, CCDS58697.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_024894.3
exon count: 21CDS single in 3' UTR: no RNA size: 3515
ORF size: 2067CDS single in intron: no Alignment % ID: 99.97
txCdsPredict score: 4184.00frame shift in genome: no % Coverage: 99.52
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.