Human Gene TMEM11 (uc002gyp.2) Description and Page Index
  Description: Homo sapiens transmembrane protein 11 (TMEM11), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr17:21,101,263-21,117,908 Size: 16,646 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg19 chr17:21,101,637-21,117,465 Size: 15,829 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr17:21,101,263-21,117,908)mRNA (may differ from genome)Protein (192 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtPubMedReactomeStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Transmembrane protein 11, mitochondrial; AltName: Full=Protein PM1; AltName: Full=Protein PMI;
FUNCTION: Plays a role in mitochondrial morphogenesis.
INTERACTION: Q12983:BNIP3; NbExp=2; IntAct=EBI-723946, EBI-749464;
SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the TMEM11 family.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): TMEM11
CDC HuGE Published Literature: TMEM11

-  MalaCards Disease Associations
  MalaCards Gene Search: TMEM11
Diseases sorted by gene-association score: penicilliosis (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 15.03 RPKM in Muscle - Skeletal
Total median expression: 299.46 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -226.50443-0.511 Picture PostScript Text
3' UTR -122.50374-0.328 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026120 - TMEM11

Pfam Domains:
PF14972 - Mitochondrial morphogenesis regulator

ModBase Predicted Comparative 3D Structure on P17152
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserGenome BrowserNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
Gene SorterGene Sorter Gene Sorter  
 Protein SequenceProtein SequenceProtein Sequence  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function
GO:0005515 protein binding

Biological Process:
GO:0007005 mitochondrion organization

Cellular Component:
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031305 integral component of mitochondrial inner membrane

-  Descriptions from all associated GenBank mRNAs
  X51804 - Human PMI gene for a putative receptor protein.
LF384745 - JP 2014500723-A/192248: Polycomb-Associated Non-Coding RNAs.
BC035874 - Homo sapiens transmembrane protein 11, mRNA (cDNA clone IMAGE:5490962), with apparent retained intron.
BC020815 - Homo sapiens transmembrane protein 11, mRNA (cDNA clone MGC:23860 IMAGE:4296149), complete cds.
BC002819 - Homo sapiens transmembrane protein 11, mRNA (cDNA clone MGC:3676 IMAGE:3636199), complete cds.
BC005268 - Homo sapiens transmembrane protein 11, mRNA (cDNA clone MGC:12310 IMAGE:4051155), complete cds.
AK311965 - Homo sapiens cDNA, FLJ92237.
BT006768 - Homo sapiens putative receptor protein mRNA, complete cds.
MA620322 - JP 2018138019-A/192248: Polycomb-Associated Non-Coding RNAs.
JD041807 - Sequence 22831 from Patent EP1572962.
JD155268 - Sequence 136292 from Patent EP1572962.
JD483460 - Sequence 464484 from Patent EP1572962.
JD367265 - Sequence 348289 from Patent EP1572962.
JD071540 - Sequence 52564 from Patent EP1572962.
JD232654 - Sequence 213678 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P17152 (Reactome details) participates in the following event(s):

R-HSA-8949613 Cristae formation
R-HSA-1592230 Mitochondrial biogenesis
R-HSA-1852241 Organelle biogenesis and maintenance

-  Other Names for This Gene
  Alternate Gene Symbols: C17orf35, NM_003876, NP_003867, P17152, PM1, Q53YB2, TMM11_HUMAN
UCSC ID: uc002gyp.2
RefSeq Accession: NM_003876
Protein: P17152 (aka TMM11_HUMAN)
CCDS: CCDS11216.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_003876.2
exon count: 2CDS single in 3' UTR: no RNA size: 1396
ORF size: 579CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1120.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.