Human Gene DPP8 (uc002aox.3) Description and Page Index
Description: Homo sapiens dipeptidyl-peptidase 8 (DPP8), transcript variant 1, mRNA. RefSeq Summary (NM_130434): This gene encodes a member of the peptidase S9B family, a small family of dipeptidyl peptidases that are able to cleave peptide substrates at a prolyl bond. The encoded protein shares similarity with dipeptidyl peptidase IV in that it is ubiquitously expressed, and hydrolyzes the same substrates. These similarities suggest that, like dipeptidyl peptidase IV, this protein may play a role in T-cell activation and immune function. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr15:65,737,998-65,810,035 Size: 72,038 Total Exon Count: 20 Strand: - Coding Region Position: hg19 chr15:65,739,222-65,804,891 Size: 65,670 Coding Exon Count: 19
ID:DPP8_HUMAN DESCRIPTION: RecName: Full=Dipeptidyl peptidase 8; Short=DP8; EC=188.8.131.52; AltName: Full=Dipeptidyl peptidase IV-related protein 1; Short=DPRP-1; AltName: Full=Dipeptidyl peptidase VIII; Short=DPP VIII; AltName: Full=Prolyl dipeptidase DPP8; FUNCTION: Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2. May play a role in T-cell activation and immune function. CATALYTIC ACTIVITY: Release of an N-terminal dipeptide, Xaa-Yaa-|- Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline. ENZYME REGULATION: Inhibited by zinc. Inhibited by the serine proteinase inhibitor 4-(2-aminoethyl)benzenesulphonyl fluoride (AEBSF), and by di-isopropylfuorophosphate. Specifically inhibited by isoindoline derivatives. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=208 uM for Ala-Pro-AMC; KM=130 uM for Ala-Pro-AFC; KM=120 uM for H-Ala-Pro-pNa; KM=1420 uM for H-Ala-Ala-pNa; KM=310 uM for H-Arg-Pro-pNa; KM=2050 uM for H-Asp-Pro-pNa; KM=480 uM for H-Gly-Pro-pNa; pH dependence: Optimum pH is 7.4-8.5. Little activity below pH 6.5; SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Ubiquitously expressed, with highest levels in testis, placenta, prostate, muscle and brain. INDUCTION: In activated T-cells. SIMILARITY: Belongs to the peptidase S9B family. DPPIV subfamily. SEQUENCE CAUTION: Sequence=AAQ13623.1; Type=Frameshift; Positions=Several; Sequence=AAQ13650.1; Type=Frameshift; Positions=Several; Sequence=AAQ13657.1; Type=Erroneous initiation; Sequence=BAA91059.1; Type=Frameshift; Positions=486; Sequence=BAB55395.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6V1X1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.