Human Gene RPAP1 (uc001zod.3) Description and Page Index
Description: Homo sapiens RNA polymerase II associated protein 1 (RPAP1), mRNA. RefSeq Summary (NM_015540): This protein forms part of the RNA polymerase II (RNAPII) enzyme complex and may recruit RNAPII to chromatin through its interaction with acetylated histones. [provided by RefSeq, Jul 2012]. ##Evidence-Data-START## Transcript exon combination :: BC000246.1, SRR1803615.29460.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000304330.9/ ENSP00000306123.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chr15:41,809,375-41,836,464 Size: 27,090 Total Exon Count: 25 Strand: - Coding Region Position: hg19 chr15:41,809,740-41,829,323 Size: 19,584 Coding Exon Count: 24
ID:RPAP1_HUMAN DESCRIPTION: RecName: Full=RNA polymerase II-associated protein 1; FUNCTION: Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Required for interaction of the RNA polymerase II complex with acetylated histone H3. SUBUNIT: Part of a RNA polymerase II complex that contains POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, RPAP1, FCP1 plus the general transcription factors TFIIB and TFIIF. SUBCELLULAR LOCATION: Nucleus (By similarity). SIMILARITY: Belongs to the RPAP1 family. SEQUENCE CAUTION: Sequence=BAA92641.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): RPAP1 CDC HuGE Published Literature: RPAP1
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BWH6
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.