Human Gene TBRG4 (uc011kcd.3)
Description: Homo sapiens transforming growth factor beta regulator 4 (TBRG4), transcript variant 4, mRNA.
Transcript (Including UTRs)
Position: hg19 chr7:45,139,699-45,151,346 Size: 11,648 Total Exon Count: 11 Strand: -
Coding Region
Position: hg19 chr7:45,139,924-45,151,268 Size: 11,345 Coding Exon Count: 11
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Primer design for this transcript
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): TBRG4
CDC HuGE Published Literature: TBRG4
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR013579 - FAST_2
IPR010622 - FAST_Leu-rich
IPR013584 - RAP
Pfam Domains: PF06743 - FAST kinase-like protein, subdomain 1
PF08368 - FAST kinase-like protein, subdomain 2
PF08373 - RAP domain
ModBase Predicted Comparative 3D Structure on B4DU42
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004672 protein kinase activity
Biological Process: GO:0006468 protein phosphorylation
Cellular Component: GO:0005739 mitochondrion
Descriptions from all associated GenBank mRNAs
KJ892722 - Synthetic construct Homo sapiens clone ccsbBroadEn_02116 TBRG4 gene, encodes complete protein.AB023165 - Homo sapiens KIAA0948 mRNA for KIAA0948 protein.AF011792 - Homo sapiens cell cycle progression 2 protein (CPR2) mRNA, complete cds.BC002732 - Homo sapiens transforming growth factor beta regulator 4, mRNA (cDNA clone IMAGE:3632005), partial cds.BC017235 - Homo sapiens transforming growth factor beta regulator 4, mRNA (cDNA clone MGC:19723 IMAGE:3538504), complete cds.BC014918 - Homo sapiens transforming growth factor beta regulator 4, mRNA (cDNA clone MGC:17875 IMAGE:3906670), complete cds.AK222943 - Homo sapiens mRNA for cell cycle progression 2 protein isoform 2 variant, clone: HRC09892.AL833840 - Homo sapiens mRNA; cDNA DKFZp727A151 (from clone DKFZp727A151).AK298155 - Homo sapiens cDNA FLJ61734 complete cds, highly similar to Homo sapiens transforming growth factor beta regulator 4 (TBRG4), transcript variant 1, mRNA.AK092132 - Homo sapiens cDNA FLJ34813 fis, clone NT2NE2007725, highly similar to Homo sapiens transforming growth factor beta regulator 4 (TBRG4), transcript variant 1, mRNA.AX747370 - Sequence 895 from Patent EP1308459.AK022575 - Homo sapiens cDNA FLJ12513 fis, clone NT2RM2001743, highly similar to Homo sapiens transforming growth factor beta regulator 4 (TBRG4), transcript variant 1, mRNA.AK300489 - Homo sapiens cDNA FLJ56153 complete cds, highly similar to Homo sapiens transforming growth factor beta regulator 4 (TBRG4), transcript variant 1, mRNA.AK001281 - Homo sapiens cDNA FLJ10419 fis, clone NT2RP1000163, highly similar to Homo sapiens transforming growth factor beta regulator 4 (TBRG4), transcript variant 3, mRNA.JD527873 - Sequence 508897 from Patent EP1572962.JD536846 - Sequence 517870 from Patent EP1572962.JD071800 - Sequence 52824 from Patent EP1572962.JD199387 - Sequence 180411 from Patent EP1572962.AB384055 - Synthetic construct DNA, clone: pF1KSDA0948, Homo sapiens TBRG4 gene for transforming growth factor beta regulator 4, complete cds, without stop codon, in Flexi system.DQ894166 - Synthetic construct Homo sapiens clone IMAGE:100008626; FLH168300.01L; RZPDo839F0191D transforming growth factor beta regulator 4 (TBRG4) gene, encodes complete protein.JD530950 - Sequence 511974 from Patent EP1572962.JD419870 - Sequence 400894 from Patent EP1572962.CU677117 - Synthetic construct Homo sapiens gateway clone IMAGE:100019965 5' read TBRG4 mRNA.JX629745 - Homo sapiens H/ACA-sno-lncRNA snoRNA, complete sequence.JD470983 - Sequence 452007 from Patent EP1572962.JD205482 - Sequence 186506 from Patent EP1572962.JD400832 - Sequence 381856 from Patent EP1572962.JD404972 - Sequence 385996 from Patent EP1572962.
Other Names for This Gene
Alternate Gene Symbols: B4DU42, B4DU42_HUMAN, NM_001261834, NP_001248763, uc011kcd.2UCSC ID: uc011kcd.3RefSeq Accession: NM_001261834
Protein: B4DU42
CCDS: CCDS5501.1
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
NM_001261834.1
exon count:
11 CDS single in 3' UTR:
no
RNA size:
2247
ORF size:
1929 CDS single in intron:
no
Alignment % ID:
100.00
txCdsPredict score:
4030.00 frame shift in genome:
no
% Coverage:
99.33
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
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Methods, Credits, and Use Restrictions
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