Human Gene SPAG7 (uc002gae.3)
  Description: Homo sapiens sperm associated antigen 7 (SPAG7), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr17:4,862,521-4,871,132 Size: 8,612 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg19 chr17:4,862,829-4,871,099 Size: 8,271 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:4,862,521-4,871,132)mRNA (may differ from genome)Protein (227 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMalacards
MGIneXtProtOMIMPubMedTreefamUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: SPAG7_HUMAN
DESCRIPTION: RecName: Full=Sperm-associated antigen 7;
SUBCELLULAR LOCATION: Nucleus (Potential).
TISSUE SPECIFICITY: Detected in fetal brain.
SIMILARITY: Contains 1 R3H domain.
SEQUENCE CAUTION: Sequence=AAC39888.1; Type=Frameshift; Positions=227;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: SPAG7
Diseases sorted by gene-association score: chronic intestinal vascular insufficiency (11), pharyngitis (9), aphthous stomatitis (7), functional gastric disease (6)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 31.10 RPKM in Muscle - Skeletal
Total median expression: 886.09 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -1.6933-0.051 Picture PostScript Text
3' UTR -108.50308-0.352 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001374 - R3H_ss-bd
IPR017330 - Sperm-assoc_antigen_PAG7

Pfam Domains:
PF01424 - R3H domain

SCOP Domains:
82708 - R3H domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2CPM - NMR MuPIT


ModBase Predicted Comparative 3D Structure on O75391
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserNo orthologNo ortholog
Gene Details  Gene Details  
Gene Sorter  Gene Sorter  
  EnsemblFlyBase  
  Protein SequenceProtein Sequence  
  AlignmentAlignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  BC007819 - Homo sapiens sperm associated antigen 7, mRNA (cDNA clone IMAGE:4303011), partial cds.
BC011934 - Homo sapiens sperm associated antigen 7, mRNA (cDNA clone MGC:20134 IMAGE:4330461), complete cds.
AF047437 - Homo sapiens sperm acrosomal protein mRNA, complete cds.
AK123065 - Homo sapiens cDNA FLJ41070 fis, clone 3NB692002685, highly similar to Homo sapiens sperm acrosomal protein mRNA.
AK312174 - Homo sapiens cDNA, FLJ92461.
KJ892801 - Synthetic construct Homo sapiens clone ccsbBroadEn_02195 SPAG7 gene, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_004890, NP_004881, O75391, Q96EU5, SPAG7_HUMAN
UCSC ID: uc002gae.3
RefSeq Accession: NM_004890
Protein: O75391 (aka SPAG7_HUMAN)
CCDS: CCDS42240.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_004890.2
exon count: 7CDS single in 3' UTR: no RNA size: 1038
ORF size: 684CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1458.00frame shift in genome: no % Coverage: 98.75
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.