Description: Homo sapiens ubiquitin-conjugating enzyme E2Q family member 1 (UBE2Q1), mRNA. RefSeq Summary (NM_017582): The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is 98% identical to the mouse counterpart. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Transcript (Including UTRs) Position: hg19 chr1:154,521,051-154,531,120 Size: 10,070 Total Exon Count: 13 Strand: - Coding Region Position: hg19 chr1:154,522,914-154,531,029 Size: 8,116 Coding Exon Count: 13
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q7Z7E8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK056388 - Homo sapiens cDNA FLJ31826 fis, clone NT2RP6000086, highly similar to Homo sapiens mRNA for NICE-5 protein. AY112698 - Homo sapiens ubiquitin-conjugating enzyme E2Q (UBE2Q) mRNA, complete cds. JD314239 - Sequence 295263 from Patent EP1572962. JD224774 - Sequence 205798 from Patent EP1572962. JD154896 - Sequence 135920 from Patent EP1572962. JD530006 - Sequence 511030 from Patent EP1572962. JD296788 - Sequence 277812 from Patent EP1572962. JD173595 - Sequence 154619 from Patent EP1572962. JD166847 - Sequence 147871 from Patent EP1572962. JD560567 - Sequence 541591 from Patent EP1572962. JD308661 - Sequence 289685 from Patent EP1572962. JD376551 - Sequence 357575 from Patent EP1572962. JD167371 - Sequence 148395 from Patent EP1572962. JD244033 - Sequence 225057 from Patent EP1572962. JD309038 - Sequence 290062 from Patent EP1572962. JD156987 - Sequence 138011 from Patent EP1572962. JD147461 - Sequence 128485 from Patent EP1572962. JD107759 - Sequence 88783 from Patent EP1572962. JD219111 - Sequence 200135 from Patent EP1572962. JD226952 - Sequence 207976 from Patent EP1572962. JD201745 - Sequence 182769 from Patent EP1572962. JD172461 - Sequence 153485 from Patent EP1572962. JD559182 - Sequence 540206 from Patent EP1572962. JD486182 - Sequence 467206 from Patent EP1572962. JD092803 - Sequence 73827 from Patent EP1572962. JD298524 - Sequence 279548 from Patent EP1572962. JD181174 - Sequence 162198 from Patent EP1572962. JD145468 - Sequence 126492 from Patent EP1572962. JD433218 - Sequence 414242 from Patent EP1572962. JD539502 - Sequence 520526 from Patent EP1572962. JD176654 - Sequence 157678 from Patent EP1572962. JD525769 - Sequence 506793 from Patent EP1572962. JD066892 - Sequence 47916 from Patent EP1572962. JD097656 - Sequence 78680 from Patent EP1572962. JD368348 - Sequence 349372 from Patent EP1572962. AK293986 - Homo sapiens cDNA FLJ56018 complete cds, highly similar to Ubiquitin-conjugating enzyme E2 Q1 (EC 6.3.2.19). BC015316 - Homo sapiens ubiquitin-conjugating enzyme E2Q family member 1, mRNA (cDNA clone IMAGE:4151953), partial cds. AF116721 - Homo sapiens PRO3094 mRNA, complete cds. AJ243666 - Homo sapiens mRNA for NICE-5 protein. BC009286 - Homo sapiens ubiquitin-conjugating enzyme E2Q (putative) 1, mRNA (cDNA clone IMAGE:3927447). BC061583 - Homo sapiens ubiquitin-conjugating enzyme E2Q family member 1, mRNA (cDNA clone IMAGE:6504049), partial cds. BC000848 - Homo sapiens ubiquitin-conjugating enzyme E2Q family member 1, mRNA (cDNA clone IMAGE:3458173), partial cds. BC087836 - Homo sapiens ubiquitin-conjugating enzyme E2Q family member 1, mRNA (cDNA clone IMAGE:6502128), partial cds. BC070158 - Homo sapiens ubiquitin-conjugating enzyme E2Q family member 1, mRNA (cDNA clone IMAGE:6717843), partial cds. JD510001 - Sequence 491025 from Patent EP1572962. BC148185 - Homo sapiens ubiquitin-conjugating enzyme E2Q family member 1, mRNA (cDNA clone IMAGE:40005749), partial cds. BC107057 - Homo sapiens ubiquitin-conjugating enzyme E2Q family member 1, mRNA (cDNA clone IMAGE:40005754), partial cds. JD061477 - Sequence 42501 from Patent EP1572962. JD412358 - Sequence 393382 from Patent EP1572962. JD057454 - Sequence 38478 from Patent EP1572962. JD358961 - Sequence 339985 from Patent EP1572962. AY948200 - Homo sapiens galactosyl transferase-associated protein (GTAP) mRNA, complete cds. JD398025 - Sequence 379049 from Patent EP1572962. JD226076 - Sequence 207100 from Patent EP1572962. CR457219 - Homo sapiens full open reading frame cDNA clone RZPDo834E0616D for gene UBE2Q, ubiquitin-conjugating enzyme E2Q (putative); complete cds, incl. stopcodon. KJ904807 - Synthetic construct Homo sapiens clone ccsbBroadEn_14201 UBE2Q1 gene, encodes complete protein. BC172317 - Synthetic construct Homo sapiens clone IMAGE:100069011, MGC:199022 ubiquitin-conjugating enzyme E2Q family member 1 (UBE2Q1) mRNA, encodes complete protein. JD019852 - Sequence 876 from Patent EP1572962. JD034406 - Sequence 15430 from Patent EP1572962. JC506671 - Sequence 39 from Patent EP2733220. JC737783 - Sequence 39 from Patent WO2014075939.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04120 - Ubiquitin mediated proteolysis
Reactome (by CSHL, EBI, and GO)
Protein Q7Z7E8 (Reactome details) participates in the following event(s):
R-HSA-983152 Transfer of ubiquitin from E1 to E2 R-HSA-983140 Transfer of Ub from E2 to substrate and release of E2 R-HSA-983157 Interaction of E3 with substrate and E2-Ub complex R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983169 Class I MHC mediated antigen processing & presentation R-HSA-1280218 Adaptive Immune System R-HSA-168256 Immune System