ID:CLVS1_HUMAN DESCRIPTION: RecName: Full=Clavesin-1; AltName: Full=Cellular retinaldehyde-binding protein-like; AltName: Full=Retinaldehyde-binding protein 1-like 1; FUNCTION: Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). SUBUNIT: Forms a complex with clathrin heavy chain and gamma- adaptin. SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein (By similarity). Cytoplasmic vesicle, clathrin-coated vesicle (By similarity). Early endosome membrane; Peripheral membrane protein. TISSUE SPECIFICITY: Expressed mainly in the brain. DOMAIN: The CRAL-TRIO domain is required for targeting to the membrane and for binding PtdIns(3,5)P2. MISCELLANEOUS: Binding to PtdIns(3,5)P2 is not required for localization. SIMILARITY: Contains 1 CRAL-TRIO domain.
Alzheimer Disease S J Furney et al. Molecular psychiatry 2011, Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease., Molecular psychiatry.
[PubMed 21116278]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8IUQ0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.