Description: Homo sapiens ATP-binding cassette, sub-family A (ABC1), member 9 (ABCA9), mRNA. RefSeq Summary (NM_080283): This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two transmembrane domains and two nucleotide binding folds. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This gene is a member of the ABC1 subfamily and is clustered with four other ABC1 family members on chromosome 17q24. Transcriptional expression of this gene is induced during monocyte differentiation into macrophages and is suppressed by cholesterol import. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr17:66,970,773-67,057,136 Size: 86,364 Total Exon Count: 39 Strand: - Coding Region Position: hg19 chr17:66,972,056-67,047,267 Size: 75,212 Coding Exon Count: 38
ID:ABCA9_HUMAN DESCRIPTION: RecName: Full=ATP-binding cassette sub-family A member 9; FUNCTION: May play a role in monocyte differentiation and lipid homeostasis. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential). TISSUE SPECIFICITY: Widely expressed with higher expression in heart. DEVELOPMENTAL STAGE: Expressed in fetal tissues with higher expression in fetal heart and kidney. INDUCTION: Up-regulated during monocyte differentiation into macrophages. Down-regulated by cholesterol loading of macrophages. SIMILARITY: Belongs to the ABC transporter superfamily. ABCA family. SIMILARITY: Contains 2 ABC transporter domains. SEQUENCE CAUTION: Sequence=AAH62472.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAC11021.1; Type=Erroneous initiation; Note=Translation N-terminally extended; WEB RESOURCE: Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http://abcmutations.hegelab.org/proteinDetails?uniprot_id=Q8IUA7";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8IUA7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000166 nucleotide binding GO:0005524 ATP binding GO:0016887 ATPase activity GO:0042626 ATPase activity, coupled to transmembrane movement of substances
Biological Process: GO:0006869 lipid transport GO:0055085 transmembrane transport
Cellular Component: GO:0016020 membrane GO:0016021 integral component of membrane GO:0043231 intracellular membrane-bounded organelle
Descriptions from all associated GenBank mRNAs
CR627382 - Homo sapiens mRNA; cDNA DKFZp686F2450 (from clone DKFZp686F2450). AK122687 - Homo sapiens cDNA FLJ16148 fis, clone BRAMY2042195, highly similar to Homo sapiens ATP-binding cassette, sub-family A (ABC1), member 8 (ABCA8). AL833712 - Homo sapiens mRNA; cDNA DKFZp667N069 (from clone DKFZp667N069). AY028899 - Homo sapiens ATP-binding cassette A9 mRNA, complete cds. AF423307 - Homo sapiens ATP-binding cassette sub-family A member 9 (ABCA9) mRNA, complete cds. BC167781 - Synthetic construct Homo sapiens clone IMAGE:100068171, MGC:195788 ATP-binding cassette, sub-family A (ABC1), member 9 (ABCA9) mRNA, encodes complete protein. JD232122 - Sequence 213146 from Patent EP1572962. JD283513 - Sequence 264537 from Patent EP1572962. JD280921 - Sequence 261945 from Patent EP1572962. JD473635 - Sequence 454659 from Patent EP1572962. JD535245 - Sequence 516269 from Patent EP1572962. JD089150 - Sequence 70174 from Patent EP1572962. JD404233 - Sequence 385257 from Patent EP1572962. JD190172 - Sequence 171196 from Patent EP1572962. JD358732 - Sequence 339756 from Patent EP1572962. JD409542 - Sequence 390566 from Patent EP1572962. JD465193 - Sequence 446217 from Patent EP1572962. JD444291 - Sequence 425315 from Patent EP1572962. JD369251 - Sequence 350275 from Patent EP1572962. JD182827 - Sequence 163851 from Patent EP1572962. JD396977 - Sequence 378001 from Patent EP1572962. JD305445 - Sequence 286469 from Patent EP1572962. JD274517 - Sequence 255541 from Patent EP1572962. JD184965 - Sequence 165989 from Patent EP1572962. JD038295 - Sequence 19319 from Patent EP1572962. JD085231 - Sequence 66255 from Patent EP1572962. JD276013 - Sequence 257037 from Patent EP1572962. JD101213 - Sequence 82237 from Patent EP1572962. JD320749 - Sequence 301773 from Patent EP1572962. AK074491 - Homo sapiens cDNA FLJ90010 fis, clone HEMBA1000349, weakly similar to ATP-BINDING CASSETTE TRANSPORTER 1. AK057068 - Homo sapiens cDNA FLJ32506 fis, clone SMINT1000042, weakly similar to ATP-BINDING CASSETTE, SUB-FAMILY A, MEMBER 3. BC062472 - Homo sapiens ATP-binding cassette, sub-family A (ABC1), member 9, mRNA (cDNA clone IMAGE:30407790), complete cds. HQ258547 - Synthetic construct Homo sapiens clone IMAGE:100072976 Unknown protein gene, complete cds. KJ902093 - Synthetic construct Homo sapiens clone ccsbBroadEn_11487 ABCA9 gene, encodes complete protein. JD290137 - Sequence 271161 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa02010 - ABC transporters
Reactome (by CSHL, EBI, and GO)
Protein Q8IUA7 (Reactome details) participates in the following event(s):