Human Gene EEF1D (uc003yyt.3) Description and Page Index
  Description: Homo sapiens eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) (EEF1D), transcript variant 3, mRNA.
RefSeq Summary (NM_001130053): This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit, delta, functions as guanine nucleotide exchange factor. It is reported that following HIV-1 infection, this subunit interacts with HIV-1 Tat. This interaction results in repression of translation of host cell proteins and enhanced translation of viral proteins. Several alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. Related pseudogenes have been defined on chromosomes 1, 6, 7, 9, 11, 13, 17, 19.[provided by RefSeq, Aug 2010].
Transcript (Including UTRs)
   Position: hg19 chr8:144,661,867-144,679,845 Size: 17,979 Total Exon Count: 10 Strand: -
Coding Region
   Position: hg19 chr8:144,661,962-144,672,251 Size: 10,290 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:144,661,867-144,679,845)mRNA (may differ from genome)Protein (647 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCLynxMGIOMIMPubMed
Stanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: D3DWK1_HUMAN
DESCRIPTION: SubName: Full=Eukaryotic translation elongation factor 1 delta (Guanine nucleotide exchange protein), isoform CRA_b;
SIMILARITY: Belongs to the EF-1-beta/EF-1-delta family.

-  MalaCards Disease Associations
  MalaCards Gene Search: EEF1D
Diseases sorted by gene-association score: cystic echinococcosis (6)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 122.51 RPKM in Ovary
Total median expression: 2956.41 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -159.80342-0.467 Picture PostScript Text
3' UTR -28.9095-0.304 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR018940 - EF-1_beta_acid_region_euk
IPR014717 - Transl_elong_EF1B/ribosomal_S6
IPR001326 - Transl_elong_EF1B_B/D_CS
IPR014038 - Transl_elong_fac_EF1B_bsu/dsu

Pfam Domains:
PF00736 - EF-1 guanine nucleotide exchange domain
PF10587 - Eukaryotic elongation factor 1 beta central acidic region

SCOP Domains:
54984 - eEF-1beta-like

ModBase Predicted Comparative 3D Structure on D3DWK1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
 Gene Details    
 Gene Sorter    
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 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003746 translation elongation factor activity

Biological Process:
GO:0006412 translation
GO:0006414 translational elongation

Cellular Component:
GO:0005853 eukaryotic translation elongation factor 1 complex


-  Descriptions from all associated GenBank mRNAs
  AL833379 - Homo sapiens mRNA; cDNA DKFZp667K1314 (from clone DKFZp667K1314).
BC000678 - Homo sapiens eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein), mRNA (cDNA clone IMAGE:3349601), partial cds.
AK093756 - Homo sapiens cDNA FLJ36437 fis, clone THYMU2012104, highly similar to ELONGATION FACTOR 1-DELTA.
AX748290 - Sequence 1815 from Patent EP1308459.
AF370363 - Homo sapiens FP1047 mRNA, complete cds.
BC071840 - Homo sapiens eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein), mRNA (cDNA clone IMAGE:5470872).
BC094806 - Homo sapiens eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein), mRNA (cDNA clone IMAGE:5442454), complete cds.
BC062535 - Homo sapiens eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein), mRNA (cDNA clone IMAGE:5017304), complete cds.
BC007847 - Homo sapiens eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein), mRNA (cDNA clone MGC:14256 IMAGE:4129368), complete cds.
BC009907 - Homo sapiens eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein), mRNA (cDNA clone IMAGE:2961609), complete cds.
BC012819 - Homo sapiens eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein), mRNA (cDNA clone IMAGE:2961609), complete cds.
Z21507 - H.sapiens EF-1delta gene encoding human elongation factor-1-delta.
AK225243 - Homo sapiens mRNA for eukaryotic translation elongation factor 1 delta isoform 1; guanine nucleotide exchange protein variant, clone: DMC01765.
AK225040 - Homo sapiens mRNA for eukaryotic translation elongation factor 1 delta isoform 1 variant, clone: adKA03573.
AK293339 - Homo sapiens cDNA FLJ57946 complete cds, highly similar to Elongation factor 1-delta.
AK225270 - Homo sapiens mRNA for eukaryotic translation elongation factor 1 delta isoform 1; guanine nucleotide exchange protein variant, clone: DMC05493.
AK024550 - Homo sapiens cDNA: FLJ20897 fis, clone ADKA03573.
JD144162 - Sequence 125186 from Patent EP1572962.
LF328359 - JP 2014500723-A/135862: Polycomb-Associated Non-Coding RNAs.
AK314311 - Homo sapiens cDNA, FLJ95068, highly similar to Homo sapiens eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) (EEF1D), transcript variant 1, mRNA.
JF432124 - Synthetic construct Homo sapiens clone IMAGE:100073263 eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) (EEF1D) gene, encodes complete protein.
KJ896746 - Synthetic construct Homo sapiens clone ccsbBroadEn_06140 EEF1D gene, encodes complete protein.
KJ905734 - Synthetic construct Homo sapiens clone ccsbBroadEn_15404 EEF1D gene, encodes complete protein.
BT007242 - Homo sapiens eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) mRNA, complete cds.
AB527761 - Synthetic construct DNA, clone: pF1KB9934, Homo sapiens EEF1D gene for eukaryotic translation elongation factor 1 delta, without stop codon, in Flexi system.
CU679527 - Synthetic construct Homo sapiens gateway clone IMAGE:100021887 5' read EEF1D mRNA.
JD158105 - Sequence 139129 from Patent EP1572962.
JD140973 - Sequence 121997 from Patent EP1572962.
DL491930 - Novel nucleic acids.
CU675829 - Synthetic construct Homo sapiens gateway clone IMAGE:100018385 5' read EEF1D mRNA.
MA563936 - JP 2018138019-A/135862: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: D3DWK1, D3DWK1_HUMAN, hCG_1994718, NM_001130053, NP_115754
UCSC ID: uc003yyt.3
RefSeq Accession: NM_001130053
Protein: D3DWK1 CCDS: CCDS6404.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001130053.2
exon count: 10CDS single in 3' UTR: no RNA size: 2381
ORF size: 1944CDS single in intron: no Alignment % ID: 99.96
txCdsPredict score: 3083.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.