Human Gene SLC39A7 (uc003odf.3) Description and Page Index
  Description: Homo sapiens solute carrier family 39 (zinc transporter), member 7 (SLC39A7), transcript variant 2, mRNA.
RefSeq Summary (NM_001077516): The protein encoded by this gene transports zinc from the Golgi and endoplasmic reticulum to the cytoplasm. This transport may be important for activation of tyrosine kinases, some of which could be involved in cancer progression. Therefore, modulation of the encoded protein could be useful as a therapeutic agent against cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].
Transcript (Including UTRs)
   Position: hg19 chr6:33,168,603-33,172,214 Size: 3,612 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg19 chr6:33,169,023-33,171,590 Size: 2,568 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr6:33,168,603-33,172,214)mRNA (may differ from genome)Protein (469 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedReactomeStanford SOURCETreefam

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Zinc transporter SLC39A7; AltName: Full=Histidine-rich membrane protein Ke4; AltName: Full=Really interesting new gene 5 protein; AltName: Full=Solute carrier family 39 member 7;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Probable).
TISSUE SPECIFICITY: Major expression in placenta, lung, kidney and pancreas.
SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): SLC39A7
CDC HuGE Published Literature: SLC39A7

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 107.74 RPKM in Pituitary
Total median expression: 2505.93 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -39.60117-0.338 Picture PostScript Text
3' UTR -253.70624-0.407 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003689 - ZIP

Pfam Domains:
PF02535 - ZIP Zinc transporter

ModBase Predicted Comparative 3D Structure on Q92504
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 Protein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005385 zinc ion transmembrane transporter activity
GO:0005515 protein binding
GO:0046873 metal ion transmembrane transporter activity

Biological Process:
GO:0006811 ion transport
GO:0006829 zinc II ion transport
GO:0006882 cellular zinc ion homeostasis
GO:0030001 metal ion transport
GO:0055085 transmembrane transport
GO:0071577 zinc II ion transmembrane transport

Cellular Component:
GO:0005654 nucleoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane

-  Descriptions from all associated GenBank mRNAs
  AK303158 - Homo sapiens cDNA FLJ52943 complete cds, highly similar to Zinc transporter SLC39A7.
AK301126 - Homo sapiens cDNA FLJ54178 complete cds, highly similar to Zinc transporter SLC39A7.
BC000645 - Homo sapiens solute carrier family 39 (zinc transporter), member 7, mRNA (cDNA clone MGC:1928 IMAGE:3345970), complete cds.
AK225282 - Homo sapiens mRNA for Zinc transporter SLC39A7 variant, clone: HEP00938.
AK225682 - Homo sapiens mRNA for Zinc transporter SLC39A7 variant, clone: SYN03265.
D82060 - Homo sapiens mRNA for membrane protein with histidine rich charge clusters, complete cds.
CU674314 - Synthetic construct Homo sapiens gateway clone IMAGE:100018323 5' read SLC39A7 mRNA.
AB590119 - Synthetic construct DNA, clone: pFN21AE1327, Homo sapiens SLC39A7 gene for solute carrier family 39 (zinc transporter), member 7, without stop codon, in Flexi system.
DQ891929 - Synthetic construct clone IMAGE:100004559; FLH181512.01X; RZPDo839E03136D solute carrier family 39 (zinc transporter), member 7 (SLC39A7) gene, encodes complete protein.
DQ895116 - Synthetic construct Homo sapiens clone IMAGE:100009576; FLH181508.01L; RZPDo839E03135D solute carrier family 39 (zinc transporter), member 7 (SLC39A7) gene, encodes complete protein.
KJ892449 - Synthetic construct Homo sapiens clone ccsbBroadEn_01843 SLC39A7 gene, encodes complete protein.
M58660 - Human MHC HLA-D region non-class II protein (RING5) mRNA, partial cds.
JD445521 - Sequence 426545 from Patent EP1572962.
JD447336 - Sequence 428360 from Patent EP1572962.
JD242149 - Sequence 223173 from Patent EP1572962.
JD375504 - Sequence 356528 from Patent EP1572962.
JD233690 - Sequence 214714 from Patent EP1572962.
JD544053 - Sequence 525077 from Patent EP1572962.
JD104967 - Sequence 85991 from Patent EP1572962.
JD115599 - Sequence 96623 from Patent EP1572962.
JD227230 - Sequence 208254 from Patent EP1572962.
JD103766 - Sequence 84790 from Patent EP1572962.
JD485439 - Sequence 466463 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q92504 (Reactome details) participates in the following event(s):

R-HSA-442393 ZIP7 mediates zinc efflux from the endoplasmic reticulum
R-HSA-442380 Zinc influx into cells by the SLC39 gene family
R-HSA-435354 Zinc transporters
R-HSA-425410 Metal ion SLC transporters
R-HSA-425366 Transport of bile salts and organic acids, metal ions and amine compounds
R-HSA-425407 SLC-mediated transmembrane transport
R-HSA-382551 Transport of small molecules

-  Other Names for This Gene
  Alternate Gene Symbols: B0UXF6, HKE4, NM_001077516, NP_008910, Q5STP8, Q92504, Q9UIQ0, RING5, S39A7_HUMAN
UCSC ID: uc003odf.3
RefSeq Accession: NM_001077516
Protein: Q92504 (aka S39A7_HUMAN)
CCDS: CCDS43453.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_001077516.1
exon count: 8CDS single in 3' UTR: no RNA size: 2172
ORF size: 1410CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3020.00frame shift in genome: no % Coverage: 99.03
has start codon: yes stop codon in genome: no # of Alignments: 6
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.