Human Gene CANX (uc003mkl.3) Description and Page Index
Description: Homo sapiens calnexin (CANX), transcript variant 2, mRNA. RefSeq Summary (NM_001024649): This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2018]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC042843.1, SRR1660809.10008.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## Transcript (Including UTRs) Position: hg19 chr5:179,125,930-179,158,639 Size: 32,710 Total Exon Count: 15 Strand: + Coding Region Position: hg19 chr5:179,132,683-179,155,645 Size: 22,963 Coding Exon Count: 14
ID:CALX_HUMAN DESCRIPTION: RecName: Full=Calnexin; AltName: Full=IP90; AltName: Full=Major histocompatibility complex class I antigen-binding protein p88; AltName: Full=p90; Flags: Precursor; FUNCTION: Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor- mediated endocytosis at the synapse. SUBUNIT: Interacts with MAPK3/ERK1. Interacts with KCNH2. Associates with ribosomes. Interacts with SGIP1; involved in negative regulation of endocytosis (By similarity). The palmitoylated form interacts with the ribosome-translocon complex component SSR1, promoting efficient folding of glycoproteins. INTERACTION: Q92597:NDRG1; NbExp=2; IntAct=EBI-355947, EBI-716486; SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. The palmitoylated form preferentially localizes to the perinuclear rough ER. PTM: Phosphorylated at Ser-564 by MAPK3/ERK1. phosphorylation by MAPK3/ERK1 increases its association with ribosomes (By similarity). PTM: Palmitoylation by DHHC6 leads to the preferential localization to the perinuclear rough ER. It mediates the association of calnexin with the ribosome-translocon complex (RTC) which is required for efficient folding of glycosylated proteins. SIMILARITY: Belongs to the calreticulin family. WEB RESOURCE: Name=Wikipedia; Note=Calnexin entry; URL="http://en.wikipedia.org/wiki/Calnexin";
Genetic Association Studies of Complex Diseases and Disorders
nephrogenic diabetes insipidus Morello JP et al. 2001, Association of calnexin with wild type and mutant AVPR2 that causes nephrogenic diabetes insipidus., Biochemistry. 2001 Jun;40(23):6766-75.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P27824
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0002474 antigen processing and presentation of peptide antigen via MHC class I GO:0006457 protein folding GO:0007568 aging GO:0009306 protein secretion GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0034975 protein folding in endoplasmic reticulum GO:0048488 synaptic vesicle endocytosis GO:0061077 chaperone-mediated protein folding GO:0070106 interleukin-27-mediated signaling pathway GO:0070757 interleukin-35-mediated signaling pathway GO:0072583 clathrin-dependent endocytosis