Human Gene JTB (uc001fds.3) Description and Page Index
  Description: Homo sapiens jumping translocation breakpoint (JTB), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr1:153,946,745-153,950,451 Size: 3,707 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chr1:153,947,155-153,949,728 Size: 2,574 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:153,946,745-153,950,451)mRNA (may differ from genome)Protein (146 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Protein JTB; AltName: Full=Jumping translocation breakpoint protein; AltName: Full=Prostate androgen-regulated protein; Short=PAR protein; Flags: Precursor;
FUNCTION: Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity).
SUBUNIT: Interacts with AURKA, AURKB, BIRC5 and INCENP. May be a component of the CPC at least composed of BIRC5/survivin, CDCA8/borealin, INCENP and AURKB/Aurora-B.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential). Mitochondrion (By similarity). Cytoplasm. Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Detected at the centrosome and along spindle fibers during prophase and metaphase. Detected at the midbody during telophase.
TISSUE SPECIFICITY: Ubiquitous. Expressed in all normal human tissues studied but overexpressed or underexpressed in many of their malignant counterparts.
INDUCTION: Protein levels increase during the S phase of the cell cycle, are highest during G2 and mitosis, and decrease to low levels at G1. Levels are lowest at the transition from G1 to S phase.
SIMILARITY: Belongs to the JTB family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 148.32 RPKM in Pituitary
Total median expression: 3730.91 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -323.60723-0.448 Picture PostScript Text
3' UTR -103.08410-0.251 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008657 - JTB

Pfam Domains:
PF05439 - Jumping translocation breakpoint protein (JTB)

Protein Data Bank (PDB) 3-D Structure
MuPIT help


ModBase Predicted Comparative 3D Structure on O76095
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserGenome BrowserNo ortholog
Gene Details  Gene DetailsGene Details 
Gene Sorter  Gene SorterGene Sorter 
  Protein SequenceProtein SequenceProtein Sequence 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0019901 protein kinase binding

Biological Process:
GO:0000278 mitotic cell cycle
GO:0000281 mitotic cytokinesis
GO:0006915 apoptotic process
GO:0007049 cell cycle
GO:0008637 apoptotic mitochondrial changes
GO:0042127 regulation of cell proliferation
GO:0045860 positive regulation of protein kinase activity
GO:0051301 cell division

Cellular Component:
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005815 microtubule organizing center
GO:0005819 spindle
GO:0005856 cytoskeleton
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030496 midbody
GO:0005813 centrosome

-  Descriptions from all associated GenBank mRNAs
  AF131797 - Homo sapiens clone 24906 hJTB protein mRNA sequence, complete cds.
BC000996 - Homo sapiens jumping translocation breakpoint, mRNA (cDNA clone MGC:5120 IMAGE:2901221), complete cds.
LF383802 - JP 2014500723-A/191305: Polycomb-Associated Non-Coding RNAs.
AF151056 - Homo sapiens HSPC222 mRNA, complete cds.
BC001667 - Homo sapiens jumping translocation breakpoint, mRNA (cDNA clone MGC:1919 IMAGE:2823348), complete cds.
BC019277 - Homo sapiens jumping translocation breakpoint, mRNA (cDNA clone MGC:3777 IMAGE:2823348), complete cds.
BC004239 - Homo sapiens jumping translocation breakpoint, mRNA (cDNA clone MGC:10274 IMAGE:3626047), complete cds.
AF115850 - Homo sapiens PAR protein mRNA, complete cds.
AB016488 - Homo sapiens hJTB mRNA, complete cds.
BC000499 - Homo sapiens jumping translocation breakpoint, mRNA (cDNA clone MGC:8413 IMAGE:2820861), complete cds.
BC001363 - Homo sapiens jumping translocation breakpoint, mRNA (cDNA clone MGC:650 IMAGE:3050800), complete cds.
LF352348 - JP 2014500723-A/159851: Polycomb-Associated Non-Coding RNAs.
JD297645 - Sequence 278669 from Patent EP1572962.
JD127383 - Sequence 108407 from Patent EP1572962.
JD086046 - Sequence 67070 from Patent EP1572962.
JD560175 - Sequence 541199 from Patent EP1572962.
JD059533 - Sequence 40557 from Patent EP1572962.
JD352403 - Sequence 333427 from Patent EP1572962.
JD146894 - Sequence 127918 from Patent EP1572962.
BT007285 - Homo sapiens jumping translocation breakpoint mRNA, complete cds.
AK312106 - Homo sapiens cDNA, FLJ92388, Homo sapiens jumping translocation breakpoint (JTB), mRNA.
KJ902172 - Synthetic construct Homo sapiens clone ccsbBroadEn_11566 JTB gene, encodes complete protein.
KJ893158 - Synthetic construct Homo sapiens clone ccsbBroadEn_02552 JTB gene, encodes complete protein.
CR456985 - Homo sapiens full open reading frame cDNA clone RZPDo834D045D for gene JTB, jumping translocation breakpoint; complete cds, incl. stopcodon.
JD264809 - Sequence 245833 from Patent EP1572962.
JD420458 - Sequence 401482 from Patent EP1572962.
JD157513 - Sequence 138537 from Patent EP1572962.
JD173708 - Sequence 154732 from Patent EP1572962.
MA619379 - JP 2018138019-A/191305: Polycomb-Associated Non-Coding RNAs.
MA587925 - JP 2018138019-A/159851: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: HSPC222, JTB_HUMAN, NM_006694, NP_006685, O76095, O95442, Q6IB19, Q9P0Q4
UCSC ID: uc001fds.3
RefSeq Accession: NM_006694
Protein: O76095 (aka JTB_HUMAN)
CCDS: CCDS1057.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_006694.3
exon count: 5CDS single in 3' UTR: no RNA size: 1574
ORF size: 441CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 650.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: yes # AT/AC introns 0
selenocysteine: no end bleed into intron: 586# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.