Human Gene CNN3 (uc001dqz.4) Description and Page Index
Description: Homo sapiens calponin 3, acidic (CNN3), mRNA. RefSeq Summary (NM_001839): This gene encodes a protein with a markedly acidic C terminus; the basic N-terminus is highly homologous to the N-terminus of a related gene, CNN1. Members of the CNN gene family all contain similar tandemly repeated motifs. This encoded protein is associated with the cytoskeleton but is not involved in contraction. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr1:95,362,507-95,392,735 Size: 30,229 Total Exon Count: 7 Strand: - Coding Region Position: hg19 chr1:95,363,298-95,392,450 Size: 29,153 Coding Exon Count: 7
ID:CNN3_HUMAN DESCRIPTION: RecName: Full=Calponin-3; AltName: Full=Calponin, acidic isoform; FUNCTION: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. TISSUE SPECIFICITY: Expressed in both non-smooth muscle tissues as well as smooth muscle tissues. SIMILARITY: Belongs to the calponin family. SIMILARITY: Contains 3 calponin-like repeats. SIMILARITY: Contains 1 CH (calponin-homology) domain.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): CNN3 CDC HuGE Published Literature: CNN3
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q15417
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.