Human Gene HMGN2 (uc001bmp.4) Description and Page Index
Description: Homo sapiens high mobility group nucleosomal binding domain 2 (HMGN2), mRNA. RefSeq Summary (NM_005517): The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMGN1, the encoded protein may help maintain an open chromatin configuration around transcribable genes. The protein has also been found to have antimicrobial activity against bacteria, viruses and fungi. [provided by RefSeq, Oct 2014]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.264967.1, SRR1803617.180791.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000361427.6/ ENSP00000355228.5 Protein has antimicrobial activity :: PMID: 16204630 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chr1:26,798,902-26,803,133 Size: 4,232 Total Exon Count: 6 Strand: + Coding Region Position: hg19 chr1:26,799,104-26,801,639 Size: 2,536 Coding Exon Count: 6
ID:HMGN2_HUMAN DESCRIPTION: RecName: Full=Non-histone chromosomal protein HMG-17; AltName: Full=High mobility group nucleosome-binding domain-containing protein 2; FUNCTION: Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in an unique chromatin conformation (By similarity). INTERACTION: P62993:GRB2; NbExp=1; IntAct=EBI-1758689, EBI-401755; SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Cytoplasmic enrichment upon phosphorylation. PTM: Phosphorylation favors cytoplasmic localization. MASS SPECTROMETRY: Mass=9261.5; Method=Electrospray; Range=2-90; Source=PubMed:10739259; MASS SPECTROMETRY: Mass=9341.3; Mass_error=1.9; Method=Electrospray; Range=2-90; Source=PubMed:10739259; MASS SPECTROMETRY: Mass=9421.5; Method=Electrospray; Range=2-90; Source=PubMed:10739259; SIMILARITY: Belongs to the HMGN family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P05204
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.