Description: Homo sapiens serine/arginine-rich splicing factor 5 (SRSF5), transcript variant 2, mRNA. RefSeq Summary (NM_006925): The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]. Transcript (Including UTRs) Position: hg19 chr14:70,233,834-70,238,722 Size: 4,889 Total Exon Count: 8 Strand: + Coding Region Position: hg19 chr14:70,234,874-70,238,178 Size: 3,305 Coding Exon Count: 7
ID:SRSF5_HUMAN DESCRIPTION: RecName: Full=Serine/arginine-rich splicing factor 5; AltName: Full=Delayed-early protein HRS; AltName: Full=Pre-mRNA-splicing factor SRP40; AltName: Full=Splicing factor, arginine/serine-rich 5; FUNCTION: Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. SUBUNIT: Interacts (via RS domain) with PHF5A (via N-terminus) (By similarity). Found in a pre-mRNA splicing complex with SRSF4/SFRS4, SRSF5/SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2. SUBCELLULAR LOCATION: Nucleus. PTM: Extensively phosphorylated on serine residues in the RS domain (By similarity). SIMILARITY: Belongs to the splicing factor SR family. SIMILARITY: Contains 2 RRM (RNA recognition motif) domains. SEQUENCE CAUTION: Sequence=AAC39543.1; Type=Frameshift; Positions=113, 140;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q13243
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC040209 - Homo sapiens splicing factor, arginine/serine-rich 5, mRNA (cDNA clone MGC:42507 IMAGE:4823314), complete cds. BX640605 - Homo sapiens mRNA; cDNA DKFZp686L2175 (from clone DKFZp686L2175); complete cds. BC095420 - Homo sapiens splicing factor, arginine/serine-rich 5, mRNA (cDNA clone IMAGE:30520500), with apparent retained intron. AK311805 - Homo sapiens cDNA, FLJ92066, Homo sapiens splicing factor, arginine/serine-rich 5 (SFRS5), mRNA. AK296113 - Homo sapiens cDNA FLJ57379 complete cds, highly similar to Splicing factor, arginine/serine-rich 5. AK300560 - Homo sapiens cDNA FLJ57437 complete cds, highly similar to Splicing factor, arginine/serine-rich 5. JD019929 - Sequence 953 from Patent EP1572962. BC018823 - Homo sapiens splicing factor, arginine/serine-rich 5, mRNA (cDNA clone MGC:1236 IMAGE:3346982), complete cds. BX247988 - human full-length cDNA clone CS0DF038YO05 of Fetal brain of Homo sapiens (human). AB209804 - Homo sapiens premature mRNA for CS0DF038YO05 variant. U30884 - Human splicing factor SRp40-2 (SRp40) mRNA, complete cds. U30826 - Human splicing factor SRp40-1 (SRp40) mRNA, complete cds. U30827 - Human splicing factor SRp40-3 (SRp40) mRNA, complete cds. JD033381 - Sequence 14405 from Patent EP1572962. AB464246 - Synthetic construct DNA, clone: pF1KB6381, Homo sapiens SFRS5 gene for splicing factor, arginine/serine-rich 5, without stop codon, in Flexi system. KJ892130 - Synthetic construct Homo sapiens clone ccsbBroadEn_01524 SRSF5 gene, encodes complete protein. AB451374 - Homo sapiens SFRS5 mRNA for splicing factor arginine/serine-rich 5, partial cds, clone: FLJ08060AAAF. CR542182 - Homo sapiens full open reading frame cDNA clone RZPDo834F0224D for gene SFRS5, splicing factor, arginine/serine-rich 5; complete cds, without stopcodon. AB451250 - Homo sapiens SFRS5 mRNA for splicing factor arginine/serine-rich 5, complete cds, clone: FLJ08060AAAN. CR542167 - Homo sapiens full open reading frame cDNA clone RZPDo834C0624D for gene SFRS5, splicing factor, arginine/serine-rich 5; complete cds, incl. stopcodon. BT007089 - Homo sapiens splicing factor, arginine/serine-rich 5 mRNA, complete cds. BC029984 - Homo sapiens splicing factor, arginine/serine-rich 5, mRNA (cDNA clone IMAGE:4214118). AF070562 - Homo sapiens clone 24529 mRNA sequence. JD526450 - Sequence 507474 from Patent EP1572962. JD396231 - Sequence 377255 from Patent EP1572962. JD396783 - Sequence 377807 from Patent EP1572962. JD043655 - Sequence 24679 from Patent EP1572962. JD306159 - Sequence 287183 from Patent EP1572962. JD426856 - Sequence 407880 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa03040 - Spliceosome
Reactome (by CSHL, EBI, and GO)
Protein Q13243 (Reactome details) participates in the following event(s):
R-HSA-72107 Formation of the Spliceosomal E complex R-HSA-75096 Docking of the TAP:EJC Complex with the NPC R-HSA-72143 Lariat Formation and 5'-Splice Site Cleavage R-HSA-72139 Formation of the active Spliceosomal C (B*) complex R-HSA-72124 Formation of the Spliceosomal A Complex R-HSA-72127 Formation of the Spliceosomal B Complex R-HSA-72130 Formation of an intermediate Spliceosomal C (Bact) complex R-HSA-8849157 TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally R-HSA-72185 mRNA polyadenylation R-HSA-72180 Cleavage of mRNA at the 3'-end R-HSA-156661 Formation of Exon Junction Complex R-HSA-159101 NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-72187 mRNA 3'-end processing R-HSA-109688 Cleavage of Growing Transcript in the Termination Region R-HSA-72172 mRNA Splicing R-HSA-72202 Transport of Mature Transcript to Cytoplasm R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA R-HSA-73856 RNA Polymerase II Transcription Termination R-HSA-8953854 Metabolism of RNA R-HSA-73857 RNA Polymerase II Transcription R-HSA-74160 Gene expression (Transcription)
US Server
