Human Gene XPO4 (uc001unq.4)
  Description: Homo sapiens exportin 4 (XPO4), mRNA.
RefSeq Summary (NM_022459): XPO4 belongs to a large family of karyopherins (see MIM 602738) that mediate the transport of proteins and other cargo between the nuclear and cytoplasmic compartments (Lipowsky et al., 2000 [PubMed 10944119]).[supplied by OMIM, Mar 2009].
Transcript (Including UTRs)
   Position: hg19 chr13:21,351,468-21,476,913 Size: 125,446 Total Exon Count: 23 Strand: -
Coding Region
   Position: hg19 chr13:21,357,861-21,476,877 Size: 119,017 Coding Exon Count: 23 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsMalaCards
CTDGene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr13:21,351,468-21,476,913)mRNA (may differ from genome)Protein (1151 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMalacards
MGIneXtProtOMIMPubMedTreefamUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: XPO4_HUMAN
DESCRIPTION: RecName: Full=Exportin-4; Short=Exp4;
FUNCTION: Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
SUBUNIT: Found in a complex with XPO4, Ran and EIF5A. Found in a complex with XPO4, Ran and SMAD3. Interacts with SMAD3. Interacts with Ran and cargo proteins in a GTP-dependent manner.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm.
SIMILARITY: Belongs to the exportin family.
SEQUENCE CAUTION: Sequence=BAB14409.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): XPO4
CDC HuGE Published Literature: XPO4
Positive Disease Associations: Bipolar Disorder , Hematocrit , Hemoglobins , Monocytes , Neuroblastoma
Related Studies:
  1. Bipolar Disorder
    , , . [PubMed 0]
  2. Hematocrit
    , , . [PubMed 0]
  3. Hemoglobins
    , , . [PubMed 0]
           more ... click here to view the complete list

-  MalaCards Disease Associations
  MalaCards Gene Search: XPO4
Diseases sorted by gene-association score: conjunctival degeneration (16), pinguecula (7)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.61 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 156.04 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -7.0036-0.194 Picture PostScript Text
3' UTR -1656.376393-0.259 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011989 - ARM-like
IPR016024 - ARM-type_fold
IPR014877 - CRM1_C_dom

Pfam Domains:
PF08767 - CRM1 C terminal

SCOP Domains:
48371 - ARM repeat

ModBase Predicted Comparative 3D Structure on Q9C0E2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologGenome BrowserNo ortholog
Gene Details   Gene Details 
Gene Sorter   Gene Sorter 
  Ensembl WormBase 
  Protein Sequence Protein Sequence 
  Alignment Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005049 nuclear export signal receptor activity
GO:0005515 protein binding
GO:0008536 Ran GTPase binding

Biological Process:
GO:0015031 protein transport
GO:0046827 positive regulation of protein export from nucleus
GO:0051168 nuclear export

Cellular Component:
GO:0005634 nucleus
GO:0005643 nuclear pore
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  AL831819 - Homo sapiens mRNA; cDNA DKFZp451H112 (from clone DKFZp451H112).
BX647843 - Homo sapiens mRNA; cDNA DKFZp451C171 (from clone DKFZp451C171).
AB051508 - Homo sapiens mRNA for KIAA1721 protein, partial cds.
BC113573 - Homo sapiens exportin 4, mRNA (cDNA clone MGC:142133 IMAGE:8322625), complete cds.
BC113571 - Homo sapiens exportin 4, mRNA (cDNA clone MGC:142131 IMAGE:8322623), complete cds.
AK057924 - Homo sapiens cDNA FLJ25195 fis, clone REC04480, highly similar to Mus musculus exportin 4 mRNA.
AK023108 - Homo sapiens cDNA FLJ13046 fis, clone NT2RP3001374.
BC042504 - Homo sapiens exportin 4, mRNA (cDNA clone IMAGE:3869183), partial cds.
AB384273 - Synthetic construct DNA, clone: pF1KSDA1721, Homo sapiens XPO4 gene for exportin-4, complete cds, without stop codon, in Flexi system.
HQ258686 - Synthetic construct Homo sapiens clone IMAGE:100072716 exportin 4 (XPO4) (XPO4) gene, encodes complete protein.
BC098402 - Homo sapiens exportin 4, mRNA (cDNA clone IMAGE:30528617), with apparent retained intron.
BC050680 - Homo sapiens exportin 4, mRNA (cDNA clone IMAGE:6143088), partial cds.
LF334607 - JP 2014500723-A/142110: Polycomb-Associated Non-Coding RNAs.
LF334606 - JP 2014500723-A/142109: Polycomb-Associated Non-Coding RNAs.
LF210106 - JP 2014500723-A/17609: Polycomb-Associated Non-Coding RNAs.
LF334674 - JP 2014500723-A/142177: Polycomb-Associated Non-Coding RNAs.
LF334675 - JP 2014500723-A/142178: Polycomb-Associated Non-Coding RNAs.
LF334676 - JP 2014500723-A/142179: Polycomb-Associated Non-Coding RNAs.
LF334678 - JP 2014500723-A/142181: Polycomb-Associated Non-Coding RNAs.
LF334680 - JP 2014500723-A/142183: Polycomb-Associated Non-Coding RNAs.
LF334681 - JP 2014500723-A/142184: Polycomb-Associated Non-Coding RNAs.
JD279214 - Sequence 260238 from Patent EP1572962.
LF334682 - JP 2014500723-A/142185: Polycomb-Associated Non-Coding RNAs.
LF334683 - JP 2014500723-A/142186: Polycomb-Associated Non-Coding RNAs.
LF334684 - JP 2014500723-A/142187: Polycomb-Associated Non-Coding RNAs.
MA570184 - JP 2018138019-A/142110: Polycomb-Associated Non-Coding RNAs.
MA570183 - JP 2018138019-A/142109: Polycomb-Associated Non-Coding RNAs.
MA445683 - JP 2018138019-A/17609: Polycomb-Associated Non-Coding RNAs.
MA570251 - JP 2018138019-A/142177: Polycomb-Associated Non-Coding RNAs.
MA570252 - JP 2018138019-A/142178: Polycomb-Associated Non-Coding RNAs.
MA570253 - JP 2018138019-A/142179: Polycomb-Associated Non-Coding RNAs.
MA570255 - JP 2018138019-A/142181: Polycomb-Associated Non-Coding RNAs.
MA570257 - JP 2018138019-A/142183: Polycomb-Associated Non-Coding RNAs.
MA570258 - JP 2018138019-A/142184: Polycomb-Associated Non-Coding RNAs.
MA570259 - JP 2018138019-A/142185: Polycomb-Associated Non-Coding RNAs.
MA570260 - JP 2018138019-A/142186: Polycomb-Associated Non-Coding RNAs.
MA570261 - JP 2018138019-A/142187: Polycomb-Associated Non-Coding RNAs.
JD080687 - Sequence 61711 from Patent EP1572962.
AK302760 - Homo sapiens cDNA FLJ57239 complete cds, highly similar to Exportin-4.

-  Other Names for This Gene
  Alternate Gene Symbols: KIAA1721, NM_022459, NP_071904, Q5VUZ5, Q8N3V6, Q9C0E2, Q9H934, XPO4_HUMAN
UCSC ID: uc001unq.4
RefSeq Accession: NM_022459
Protein: Q9C0E2 (aka XPO4_HUMAN)
CCDS: CCDS41872.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_022459.4
exon count: 23CDS single in 3' UTR: no RNA size: 9902
ORF size: 3456CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 7088.00frame shift in genome: no % Coverage: 99.83
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 1
selenocysteine: no end bleed into intron: 0# strange splices: 1
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.