ID:TTC5_HUMAN DESCRIPTION: RecName: Full=Tetratricopeptide repeat protein 5; Short=TPR repeat protein 5; AltName: Full=Stress-responsive activator of p300; Short=Strap; FUNCTION: Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2 (By similarity). SUBUNIT: Interacts with JMY and p300/EP300 (By similarity). SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Phosphorylation at Ser-203 results in nuclear localization, while unphosphorylated protein localizes to the cytoplasm (By similarity). PTM: Phosphorylation at Ser-203 enhances protein stability, regulates nuclear accumulation and association with p300/EP300 (By similarity). SIMILARITY: Contains 6 TPR repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8N0Z6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006281 DNA repair GO:0006974 cellular response to DNA damage stimulus GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:1901796 regulation of signal transduction by p53 class mediator
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