ID:PAN3_HUMAN DESCRIPTION: RecName: Full=PAB-dependent poly(A)-specific ribonuclease subunit 3; Short=hPan3; FUNCTION: Functions in cytoplasmic mRNA decay. As part of the Pan nuclease complex, recruits polyadenylate-binding protein which in turn stimulates PAN2 nuclease activity. SUBUNIT: Interacts with PAN2 to form the Pan nuclease complex. Mediates the interaction of the Pan nuclease complex with polyadenylate-binding protein. SUBCELLULAR LOCATION: Cytoplasm. DOMAIN: The protein kinase domain is predicted to be catalytically inactive. SIMILARITY: Belongs to the protein kinase superfamily. SIMILARITY: Contains 1 C3H1-type zinc finger. SIMILARITY: Contains 1 protein kinase domain. SEQUENCE CAUTION: Sequence=AAI28180.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=ABK41888.1; Type=Erroneous gene model prediction; Sequence=BAC03632.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAI12449.2; Type=Erroneous gene model prediction; Sequence=CAI12450.2; Type=Erroneous gene model prediction; Sequence=CAI14848.1; Type=Erroneous gene model prediction; Sequence=CAM20921.1; Type=Erroneous gene model prediction; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/pan3/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q58A45
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.