Description: Homo sapiens neuromedin B (NMB), transcript variant 2, mRNA. RefSeq Summary (NM_205858): This gene encodes a member of the bombesin-like family of neuropeptides, which negatively regulate eating behavior. The encoded protein may regulate colonic smooth muscle contraction through binding to its cognate receptor, the neuromedin B receptor (NMBR). Polymorphisms of this gene may be associated with hunger, weight gain and obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]. Transcript (Including UTRs) Position: hg19 chr15:85,198,360-85,201,802 Size: 3,443 Total Exon Count: 3 Strand: - Coding Region Position: hg19 chr15:85,198,501-85,201,383 Size: 2,883 Coding Exon Count: 3
To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): NMB CDC HuGE Published Literature: NMB Positive Disease Associations: Body Weight Regulation
, obesity Related Studies:
Body Weight Regulation Oeffner F et al. 2000, Significant association between a silent polymorphism in the neuromedin B gene and body weight in German children and adolescents., Acta diabetologica. 2000 ;37(2):93-101.
[PubMed 11194934]
These results suggest a contribution of NMB or a gene in its close vicinity to genetic weight control in humans.
obesity Oeffner, F. et al. 2000, Significant association between a silent polymorphism in the neuromedin B gene and body weight in German children and adolescents, Acta diabetologica. 2000 ;37(2):93-101.
[PubMed 11194934]
These results suggest a contribution of NMB or a gene in its close vicinity to genetic weight control in humans.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P08949-2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
