Human Gene C8orf58 (uc003xce.3)
  Description: Homo sapiens chromosome 8 open reading frame 58 (C8orf58), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr8:22,457,114-22,461,662 Size: 4,549 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chr8:22,457,234-22,460,819 Size: 3,586 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:22,457,114-22,461,662)mRNA (may differ from genome)Protein (365 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMGIneXtProt
PubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CH058_HUMAN
DESCRIPTION: RecName: Full=Uncharacterized protein C8orf58;
SEQUENCE CAUTION: Sequence=BAC03795.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 19.64 RPKM in Testis
Total median expression: 255.49 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -65.60120-0.547 Picture PostScript Text
3' UTR -294.15843-0.349 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF15552 - Domain of unknown function (DUF4657)

ModBase Predicted Comparative 3D Structure on Q8NAV2
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Descriptions from all associated GenBank mRNAs
  AK295405 - Homo sapiens cDNA FLJ56347 complete cds.
LP896504 - Sequence 1368 from Patent EP3253886.
LF210144 - JP 2014500723-A/17647: Polycomb-Associated Non-Coding RNAs.
AK092034 - Homo sapiens cDNA FLJ34715 fis, clone MESAN2004575.
AX747326 - Sequence 851 from Patent EP1308459.
BC012750 - Homo sapiens chromosome 8 open reading frame 58, mRNA (cDNA clone MGC:16089 IMAGE:3618901), complete cds.
JD463689 - Sequence 444713 from Patent EP1572962.
JD086602 - Sequence 67626 from Patent EP1572962.
JD074594 - Sequence 55618 from Patent EP1572962.
JD203919 - Sequence 184943 from Patent EP1572962.
CU680390 - Synthetic construct Homo sapiens gateway clone IMAGE:100022385 5' read C8orf58 mRNA.
HQ447698 - Synthetic construct Homo sapiens clone IMAGE:100071026; CCSB013463_01 chromosome 8 open reading frame 58 (C8orf58) gene, encodes complete protein.
KJ904315 - Synthetic construct Homo sapiens clone ccsbBroadEn_13709 C8orf58 gene, encodes complete protein.
LF335089 - JP 2014500723-A/142592: Polycomb-Associated Non-Coding RNAs.
DQ593874 - Homo sapiens piRNA piR-33986, complete sequence.
JD264411 - Sequence 245435 from Patent EP1572962.
JD479371 - Sequence 460395 from Patent EP1572962.
JD199039 - Sequence 180063 from Patent EP1572962.
JD258089 - Sequence 239113 from Patent EP1572962.
JD047831 - Sequence 28855 from Patent EP1572962.
JD291053 - Sequence 272077 from Patent EP1572962.
JD393285 - Sequence 374309 from Patent EP1572962.
JD133017 - Sequence 114041 from Patent EP1572962.
JD361705 - Sequence 342729 from Patent EP1572962.
JD331953 - Sequence 312977 from Patent EP1572962.
JD491609 - Sequence 472633 from Patent EP1572962.
JD421061 - Sequence 402085 from Patent EP1572962.
MA445721 - JP 2018138019-A/17647: Polycomb-Associated Non-Coding RNAs.
MA570666 - JP 2018138019-A/142592: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: B4DI44, CH058_HUMAN, NM_001013842, NP_001013864, Q8NAV2
UCSC ID: uc003xce.3
RefSeq Accession: NM_001013842
Protein: Q8NAV2 (aka CH058_HUMAN)
CCDS: CCDS34862.1, CCDS56527.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001013842.2
exon count: 7CDS single in 3' UTR: no RNA size: 2062
ORF size: 1098CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2396.00frame shift in genome: no % Coverage: 99.95
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.