Description: Homo sapiens casein kinase 1, gamma 3 (CSNK1G3), transcript variant 4, mRNA. RefSeq Summary (NM_001044723): This gene encodes a member of a family of serine/threonine protein kinases that phosphorylate caseins and other acidic proteins. A related protein in the African clawed frog participates in the transmission of Wnt/beta-catenin signaling. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]. Transcript (Including UTRs) Position: hg19 chr5:122,881,111-122,952,738 Size: 71,628 Total Exon Count: 13 Strand: + Coding Region Position: hg19 chr5:122,881,358-122,950,090 Size: 68,733 Coding Exon Count: 13
Amyotrophic lateral sclerosis Landers ,et al. 2009, Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis, Proceedings of the National Academy of Sciences of the United States of America 2009 106- 22 : 9004-9.
[PubMed 19451621]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF00069 - Protein kinase domain PF07714 - Protein tyrosine kinase PF12605 - Casein kinase 1 gamma C terminal
SCOP Domains: 56112 - Protein kinase-like (PK-like)
ModBase Predicted Comparative 3D Structure on Q9Y6M4-2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.