Human Gene CSNK1G3 (uc031skv.1)
  Description: Homo sapiens casein kinase 1, gamma 3 (CSNK1G3), transcript variant 4, mRNA.
RefSeq Summary (NM_001044723): This gene encodes a member of a family of serine/threonine protein kinases that phosphorylate caseins and other acidic proteins. A related protein in the African clawed frog participates in the transmission of Wnt/beta-catenin signaling. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012].
Transcript (Including UTRs)
   Position: hg19 chr5:122,881,111-122,952,738 Size: 71,628 Total Exon Count: 13 Strand: +
Coding Region
   Position: hg19 chr5:122,881,358-122,950,090 Size: 68,733 Coding Exon Count: 13 

Page IndexSequence and LinksPrimersGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:122,881,111-122,952,738)mRNA (may differ from genome)Protein (455 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCLynxMGIOMIM
PubMedUniProtKBBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): CSNK1G3
CDC HuGE Published Literature: CSNK1G3
Positive Disease Associations: Amyotrophic lateral sclerosis
Related Studies:
  1. Amyotrophic lateral sclerosis
    Landers ,et al. 2009, Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis, Proceedings of the National Academy of Sciences of the United States of America 2009 106- 22 : 9004-9. [PubMed 19451621]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.96 RPKM in Cells - Cultured fibroblasts
Total median expression: 268.00 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -45.00247-0.182 Picture PostScript Text
3' UTR -607.792648-0.230 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00069 - Protein kinase domain
PF07714 - Protein tyrosine kinase
PF12605 - Casein kinase 1 gamma C terminal

SCOP Domains:
56112 - Protein kinase-like (PK-like)

ModBase Predicted Comparative 3D Structure on Q9Y6M4-2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Descriptions from all associated GenBank mRNAs
  AK316019 - Homo sapiens cDNA, FLJ78918 complete cds, highly similar to Mus musculus casein kinase 1, gamma 3 (Csnk1g3).
AK299739 - Homo sapiens cDNA FLJ50193 complete cds, highly similar to Homo sapiens casein kinase 1, gamma 3 (CSNK1G3), transcript variant 2, mRNA.
BC047567 - Homo sapiens casein kinase 1, gamma 3, mRNA (cDNA clone MGC:48323 IMAGE:4817058), complete cds.
AK289405 - Homo sapiens cDNA FLJ76641 complete cds, highly similar to Homo sapiens casein kinase 1, gamma 3 (CSNK1G3), transcript variant 2, mRNA.
AF049089 - Homo sapiens casein kinase I gamma 3 (CSNK1G3) mRNA, complete cds.
AF049090 - Homo sapiens casein kinase I gamma 3L (CSNK1G3L) mRNA, complete cds.
AB587536 - Synthetic construct DNA, clone: pF1KE0784, Homo sapiens CSNK1G3 gene for casein kinase 1, gamma 3, without stop codon, in Flexi system.
KJ896663 - Synthetic construct Homo sapiens clone ccsbBroadEn_06057 CSNK1G3 gene, encodes complete protein.
BC020649 - Homo sapiens cDNA clone IMAGE:4666451, **** WARNING: chimeric clone ****.
JD096796 - Sequence 77820 from Patent EP1572962.
JD255897 - Sequence 236921 from Patent EP1572962.
JD112919 - Sequence 93943 from Patent EP1572962.
JD084894 - Sequence 65918 from Patent EP1572962.
JD379854 - Sequence 360878 from Patent EP1572962.
JD296249 - Sequence 277273 from Patent EP1572962.
JD051568 - Sequence 32592 from Patent EP1572962.
JD171736 - Sequence 152760 from Patent EP1572962.
JD244195 - Sequence 225219 from Patent EP1572962.
JD328685 - Sequence 309709 from Patent EP1572962.
JD051453 - Sequence 32477 from Patent EP1572962.
JD456091 - Sequence 437115 from Patent EP1572962.
JD036534 - Sequence 17558 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04340 - Hedgehog signaling pathway

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001044723, NP_001038188, Q9Y6M4-2, uc003ktl.3
UCSC ID: uc031skv.1
RefSeq Accession: NM_001044723
Protein: Q9Y6M4-2, splice isoform of Q9Y6M4 CCDS: CCDS4135.1, CCDS43355.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001044723.2
exon count: 13CDS single in 3' UTR: no RNA size: 4275
ORF size: 1368CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2811.50frame shift in genome: no % Coverage: 99.72
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.