Human Gene AGFG1 (uc002vpd.2) Description and Page Index
Description: Homo sapiens ArfGAP with FG repeats 1 (AGFG1), transcript variant 1, mRNA. RefSeq Summary (NM_001135187): The protein encoded by this gene is related to nucleoporins, a class of proteins that mediate nucleocytoplasmic transport. The encoded protein binds the activation domain of the human immunodeficiency virus Rev protein when Rev is assembled onto its RNA target, and is required for the nuclear export of Rev-directed RNAs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]. Transcript (Including UTRs) Position: hg19 chr2:228,336,888-228,425,938 Size: 89,051 Total Exon Count: 14 Strand: + Coding Region Position: hg19 chr2:228,337,138-228,419,211 Size: 82,074 Coding Exon Count: 14
ID:E9PHX7_HUMAN DESCRIPTION: SubName: Full=Arf-GAP domain and FG repeat-containing protein 1; SIMILARITY: Contains 1 Arf-GAP domain. CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): AGFG1 CDC HuGE Published Literature: AGFG1
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF01412 - Putative GTPase activating protein for Arf
SCOP Domains: 57863 - Pyk2-associated protein beta ARF-GAP domain
ModBase Predicted Comparative 3D Structure on E9PHX7
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.