Human Gene PRAMEF8 (uc001aup.3) Description and Page Index
  Description: Homo sapiens PRAME family member 8 (PRAMEF8), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr1:12,976,450-12,980,568 Size: 4,119 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr1:12,977,513-12,980,233 Size: 2,721 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:12,976,450-12,980,568)mRNA (may differ from genome)Protein (474 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSCGAP
EnsemblEntrez GeneExonPrimerGeneCardsGeneNetworkHGNC
HPRDLynxMGIneXtProtPubMedStanford SOURCE

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=PRAME family member 8;
SIMILARITY: Belongs to the PRAME family.
SIMILARITY: Contains 2 LRR (leucine-rich) repeats.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • C009505 4,4'-diaminodiphenylmethane
  • D018817 N-Methyl-3,4-methylenedioxyamphetamine

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.00 RPKM in Adipose - Subcutaneous
Total median expression: 0.00 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -12.7083-0.153 Picture PostScript Text
3' UTR -93.11335-0.278 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026292 - PRAME/Leu_rich_rep-con_p14
IPR026271 - PRAME_family

SCOP Domains:
52047 - RNI-like
52058 - L domain-like
52075 - Outer arm dynein light chain 1

ModBase Predicted Comparative 3D Structure on Q5VWM4
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0008284 positive regulation of cell proliferation
GO:0043066 negative regulation of apoptotic process
GO:0045596 negative regulation of cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated

-  Descriptions from all associated GenBank mRNAs
  BC140755 - Homo sapiens PRAME family member 7, mRNA (cDNA clone MGC:176432 IMAGE:9021623), complete cds.
BC144565 - Homo sapiens PRAME family member 8, mRNA (cDNA clone MGC:178110 IMAGE:9053093), complete cds.
LF206892 - JP 2014500723-A/14395: Polycomb-Associated Non-Coding RNAs.
LF359036 - JP 2014500723-A/166539: Polycomb-Associated Non-Coding RNAs.
MA442469 - JP 2018138019-A/14395: Polycomb-Associated Non-Coding RNAs.
MA594613 - JP 2018138019-A/166539: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001012276, NP_001012277, PRAM8_HUMAN, Q5VWM4
UCSC ID: uc001aup.3
RefSeq Accession: NM_001012276
Protein: Q5VWM4 (aka PRAM8_HUMAN)
CCDS: CCDS30593.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_001012276.1
exon count: 4CDS single in 3' UTR: no RNA size: 1844
ORF size: 1425CDS single in intron: no Alignment % ID: 99.84
txCdsPredict score: 2552.00frame shift in genome: no % Coverage: 99.95
has start codon: yes stop codon in genome: no # of Alignments: 3
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.