Human Gene ARL15 (uc003jpg.1)
  Description: Homo sapiens ADP-ribosylation factor-like 15 (ARL15), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr5:53,180,614-53,606,403 Size: 425,790 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chr5:53,182,391-53,606,309 Size: 423,919 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:53,180,614-53,606,403)mRNA (may differ from genome)Protein (204 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ARL15_HUMAN
DESCRIPTION: RecName: Full=ADP-ribosylation factor-like protein 15; AltName: Full=ADP-ribosylation factor-related protein 2; Short=ARF-related protein 2;
SIMILARITY: Belongs to the small GTPase superfamily. Arf family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): ARL15
CDC HuGE Published Literature: ARL15
Positive Disease Associations: Adiponectin , Adiponectin levels , Body Weight , Cholesterol, HDL , Macular Degeneration , Myocardial Infarction , Uric Acid
Related Studies:
  1. Adiponectin
    J Brent Richards et al. PLoS genetics 2009, A genome-wide association study reveals variants in ARL15 that influence adiponectin levels., PLoS genetics. [PubMed 20011104]
  2. Adiponectin
    Zari Dastani et al. PLoS genetics 2012, Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals., PLoS genetics. [PubMed 22479202]
  3. Adiponectin levels
    Richards ,et al. 2009, A genome-wide association study reveals variants in ARL15 that influence adiponectin levels, PLoS genetics 2009 5- 12 : e1000768. [PubMed 20011104]
           more ... click here to view the complete list

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.33 RPKM in Breast - Mammary Tissue
Total median expression: 216.83 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -31.6094-0.336 Picture PostScript Text
3' UTR -412.171777-0.232 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR024156 - Small_GTPase_ARF
IPR006689 - Small_GTPase_ARF/SAR

Pfam Domains:
PF00025 - ADP-ribosylation factor family
PF00071 - Ras family
PF08477 - Ras of Complex, Roc, domain of DAPkinase
PF09439 - Signal recognition particle receptor beta subunit

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases

ModBase Predicted Comparative 3D Structure on Q9NXU5
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Ensembl   
  Protein Sequence   
  Alignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003674 molecular_function
GO:0005525 GTP binding

Biological Process:
GO:0008150 biological_process

Cellular Component:
GO:0005622 intracellular
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  AK000058 - Homo sapiens cDNA FLJ20051 fis, clone COL00720.
BC026093 - Homo sapiens ADP-ribosylation factor-like 15, mRNA (cDNA clone MGC:27143 IMAGE:4699068), complete cds.
AK311482 - Homo sapiens cDNA, FLJ18524.
AK290886 - Homo sapiens cDNA FLJ77904 complete cds, highly similar to Homo sapiens ADP-ribosylation factor-like 15, mRNA.
CU693132 - Synthetic construct Homo sapiens gateway clone IMAGE:100022152 5' read ARL15 mRNA.
HQ447680 - Synthetic construct Homo sapiens clone IMAGE:100071121; CCSB013164_01 ADP-ribosylation factor-like 15 (ARL15) gene, encodes complete protein.
KJ899003 - Synthetic construct Homo sapiens clone ccsbBroadEn_08397 ARL15 gene, encodes complete protein.
CR457225 - Homo sapiens full open reading frame cDNA clone RZPDo834G118D for gene ARFRP2, ADP-ribosylation factor related protein 2; complete cds, incl. stopcodon.
AX772814 - Sequence 11 from Patent WO03046180.
JD171409 - Sequence 152433 from Patent EP1572962.
JD097799 - Sequence 78823 from Patent EP1572962.
JD490134 - Sequence 471158 from Patent EP1572962.
JD113092 - Sequence 94116 from Patent EP1572962.
JD078433 - Sequence 59457 from Patent EP1572962.
JD171845 - Sequence 152869 from Patent EP1572962.
JD377902 - Sequence 358926 from Patent EP1572962.
JD224134 - Sequence 205158 from Patent EP1572962.
JD552215 - Sequence 533239 from Patent EP1572962.
JD239201 - Sequence 220225 from Patent EP1572962.
JD507716 - Sequence 488740 from Patent EP1572962.
JD163018 - Sequence 144042 from Patent EP1572962.
JD069460 - Sequence 50484 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ARFRP2, ARL15_HUMAN, NM_019087, NP_061960, Q6IAD0, Q9NXU5
UCSC ID: uc003jpg.1
RefSeq Accession: NM_019087
Protein: Q9NXU5 (aka ARL15_HUMAN)
CCDS: CCDS54850.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_019087.2
exon count: 5CDS single in 3' UTR: no RNA size: 2501
ORF size: 615CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1335.50frame shift in genome: no % Coverage: 99.40
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.