Description: Homo sapiens carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 (CHST5), mRNA. RefSeq Summary (NM_024533): The protein encoded by this gene belongs to the Gal/GalNAc/GlcNAc 6-O-sulfotransferase (GST) family, members of which catalyze the transfer of sulfate to position 6 of galactose (Gal), N-acetylgalactosamine (GalNAc), or N-acetylglucosamine (GlcNAc) residues within proteoglycans, and sulfation of O-linked sugars of mucin-type acceptors. Carbohydrate sulfation plays a critical role in many biologic processes. This gene is predominantly expressed in colon and small intestine. [provided by RefSeq, Aug 2011]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Transcript (Including UTRs) Position: hg19 chr16:75,562,428-75,569,068 Size: 6,641 Total Exon Count: 3 Strand: - Coding Region Position: hg19 chr16:75,563,047-75,564,282 Size: 1,236 Coding Exon Count: 1
ID:CHST5_HUMAN DESCRIPTION: RecName: Full=Carbohydrate sulfotransferase 5; EC=2.8.2.-; AltName: Full=Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 4-alpha; Short=GST4-alpha; AltName: Full=Intestinal N-acetylglucosamine-6-O-sulfotransferase; Short=I-GlcNAc6ST; Short=Intestinal GlcNAc-6-sulfotransferase; Short=hIGn6ST; AltName: Full=N-acetylglucosamine 6-O-sulfotransferase 3; Short=GlcNAc6ST-3; Short=Gn6st-3; FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues and O-linked sugars of mucin-type acceptors. Acts on the non-reducing terminal GlcNAc of short carbohydrate substrates. However, it does not transfer sulfate to longer carbohydrate substrates that have poly-N-acetyllactosamine structures. Has no activity toward keratan. Not involved in generating HEV-expressed ligands for SELL. Its substrate specificity may be influenced by its subcellular location. SUBCELLULAR LOCATION: Golgi apparatus membrane; Single-pass type II membrane protein (Probable). Note=Golgi membrane, early secretory pathway. TISSUE SPECIFICITY: Predominantly expressed in small and large intestines and colon. Weakly expressed in lymphocytes. Not expressed in other tissues. Down-regulated in colonic adenocarcinomas. SIMILARITY: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily. SEQUENCE CAUTION: Sequence=AAD56000.1; Type=Erroneous initiation; Sequence=AAD56001.1; Type=Erroneous initiation; WEB RESOURCE: Name=GGDB; Note=GlycoGene database; URL="http://riodb.ibase.aist.go.jp/rcmg/ggdb/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9GZS9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0005975 carbohydrate metabolic process GO:0006044 N-acetylglucosamine metabolic process GO:0006477 protein sulfation GO:0006790 sulfur compound metabolic process GO:0018146 keratan sulfate biosynthetic process
US Server
