Description: Homo sapiens mitochondrial ribosomal protein L20 (MRPL20), nuclear gene encoding mitochondrial protein, mRNA. RefSeq Summary (NM_017971): Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 21q. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]. Transcript (Including UTRs) Position: hg19 chr1:1,337,276-1,342,693 Size: 5,418 Total Exon Count: 4 Strand: - Coding Region Position: hg19 chr1:1,337,463-1,342,597 Size: 5,135 Coding Exon Count: 4
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BYC9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC059945 - Homo sapiens mitochondrial ribosomal protein L20, mRNA (cDNA clone MGC:74465 IMAGE:5397911), complete cds. BC071836 - Homo sapiens cDNA clone IMAGE:6210072, **** WARNING: chimeric clone ****. BC098413 - Homo sapiens cDNA clone IMAGE:6208834, **** WARNING: chimeric clone ****. AK000886 - Homo sapiens cDNA FLJ10024 fis, clone HEMBA1000636. BC014316 - Homo sapiens mitochondrial ribosomal protein L20, mRNA (cDNA clone MGC:22703 IMAGE:4045076), complete cds. AB049644 - Homo sapiens MRPL20 mRNA for mitochondrial ribosomal protein L20 (L20mt), complete cds. BC009515 - Homo sapiens mitochondrial ribosomal protein L20, mRNA (cDNA clone MGC:4779 IMAGE:3542715), complete cds. JD491388 - Sequence 472412 from Patent EP1572962. AK315794 - Homo sapiens cDNA, FLJ96914, Homo sapiens mitochondrial ribosomal protein L20 (MRPL20), nucleargene encoding mitochondrial protein, mRNA. KJ899069 - Synthetic construct Homo sapiens clone ccsbBroadEn_08463 MRPL20 gene, encodes complete protein. KJ906214 - Synthetic construct Homo sapiens clone ccsbBroadEn_15884 MRPL20 gene, encodes complete protein. AK301440 - Homo sapiens cDNA FLJ57630 complete cds, moderately similar to Homo sapiens mitochondrial ribosomal protein L20 (MRPL20), mRNA.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9BYC9 (Reactome details) participates in the following event(s):
R-HSA-5389839 39S subunit binds 28S subunit:mRNA:fMet-tRNA R-HSA-5419273 Hydrolysis of GTP and dissociation of 28S and 39S subunits R-HSA-5389848 TUFM:GTP:aminoacyl-tRNA binds 55S ribosome:mRNA:fMet-tRNA R-HSA-5389857 Peptide transfer from P-site to A-site (peptide bond formation) R-HSA-5389842 TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome R-HSA-5419261 55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP R-HSA-5419281 MRRF binds 55S ribosome:mRNA:tRNA R-HSA-5419279 Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA) R-HSA-5419264 MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA R-HSA-5419277 GFM2:GTP binds 55S ribosome:mRNA:tRNA:MRRF releasing mRNA and tRNA R-HSA-5368286 Mitochondrial translation initiation R-HSA-5419276 Mitochondrial translation termination R-HSA-5368287 Mitochondrial translation R-HSA-5389840 Mitochondrial translation elongation R-HSA-72766 Translation R-HSA-392499 Metabolism of proteins
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