ID:RPP40_HUMAN DESCRIPTION: RecName: Full=Ribonuclease P protein subunit p40; Short=RNaseP protein p40; EC=3.1.26.5; AltName: Full=RNase P subunit 1; FUNCTION: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. CATALYTIC ACTIVITY: Endonucleolytic cleavage of RNA, removing 5'- extranucleotides from tRNA precursor. SUBUNIT: RNase P consists of a RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. SUBCELLULAR LOCATION: Nucleus, nucleolus (Potential). SEQUENCE CAUTION: Sequence=AAC24114.1; Type=Erroneous initiation; Sequence=AAH17871.1; Type=Frameshift; Positions=327; Sequence=CAH73740.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF08584 - Ribonuclease P 40kDa (Rpp40) subunit
ModBase Predicted Comparative 3D Structure on O75818
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
