Description: Homo sapiens growth differentiation factor 11 (GDF11), mRNA. RefSeq Summary (NM_005811): This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein plays a role in the development of the nervous and other organ systems, and may regulate aging. [provided by RefSeq, Aug 2016]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Transcript (Including UTRs) Position: hg19 chr12:56,137,064-56,146,665 Size: 9,602 Total Exon Count: 3 Strand: + Coding Region Position: hg19 chr12:56,137,101-56,143,666 Size: 6,566 Coding Exon Count: 3
ID:GDF11_HUMAN DESCRIPTION: RecName: Full=Growth/differentiation factor 11; Short=GDF-11; AltName: Full=Bone morphogenetic protein 11; Short=BMP-11; Flags: Precursor; FUNCTION: Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern. SUBUNIT: Homodimer; disulfide-linked (By similarity). SUBCELLULAR LOCATION: Secreted (Probable). SIMILARITY: Belongs to the TGF-beta family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O95390
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001501 skeletal system development GO:0001656 metanephros development GO:0001657 ureteric bud development GO:0007399 nervous system development GO:0007498 mesoderm development GO:0008285 negative regulation of cell proliferation GO:0009887 animal organ morphogenesis GO:0009952 anterior/posterior pattern specification GO:0010469 regulation of receptor activity GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0021512 spinal cord anterior/posterior patterning GO:0031016 pancreas development GO:0042981 regulation of apoptotic process GO:0043408 regulation of MAPK cascade GO:0045596 negative regulation of cell differentiation GO:0045665 negative regulation of neuron differentiation GO:0048468 cell development GO:0048469 cell maturation GO:0048593 camera-type eye morphogenesis GO:0060021 palate development GO:0060395 SMAD protein signal transduction
US Server
