Description: Homo sapiens tRNA methyltransferase 6 homolog (S. cerevisiae) (TRMT6), mRNA. RefSeq Summary (NM_015939): This gene encodes a member of the tRNA methyltransferase 6 protein family. A similar protein in yeast is part of a two component methyltransferase, which is involved in the posttranslational modification that produces the modified nucleoside 1-methyladenosine in tRNAs. Modified 1-methyladenosine influences initiator methionine stability and may be involved in the replication of human immunodeficiency virus type 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]. Transcript (Including UTRs) Position: hg19 chr20:5,918,486-5,931,173 Size: 12,688 Total Exon Count: 11 Strand: - Coding Region Position: hg19 chr20:5,919,181-5,931,051 Size: 11,871 Coding Exon Count: 11
ID:TRM6_HUMAN DESCRIPTION: RecName: Full=tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; AltName: Full=tRNA(m1A58)-methyltransferase subunit TRM6; Short=tRNA(m1A58)MTase subunit TRM6; FUNCTION: Substrate-binding subunit of tRNA (adenine-N(1)-)- methyltransferase, which catalyzes the formation of N(1)- methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. SUBUNIT: tRNA (adenine-N(1)-)-methyltransferase is a heterodimer of TRM6 and TRM61. SUBCELLULAR LOCATION: Nucleus (By similarity). TISSUE SPECIFICITY: Expressed in brain, liver, testis and ovary. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the TRM6/GCD10 family. SEQUENCE CAUTION: Sequence=BAA86467.1; Type=Erroneous initiation; Sequence=BAA86467.1; Type=Frameshift; Positions=319;
menarche and menopause (age at onset) He ,et al. 2009, Genome-wide association studies identify loci associated with age at menarche and age at natural menopause, Nature genetics 2009 .
[PubMed 19448621]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UJA5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Protein Q9UJA5 (Reactome details) participates in the following event(s):
R-HSA-6783492 TRMT6:TRMT61A methylate adenosine yielding 1-methyladenosine at nucleotide 58 of tRNA(Met) R-HSA-6782315 tRNA modification in the nucleus and cytosol R-HSA-72306 tRNA processing R-HSA-8953854 Metabolism of RNA