Human Gene MYADML (uc002rpb.3)
  Description: Homo sapiens myeloid-associated differentiation marker-like (pseudogene) (MYADML), non-coding RNA.
Transcript (Including UTRs)
   Position: hg19 chr2:33,951,128-33,953,284 Size: 2,157 Total Exon Count: 1 Strand: -
Coding Region
   Position: hg19 chr2:33,952,105-33,952,842 Size: 738 Coding Exon Count: 1 

Page IndexSequence and LinksPrimersGenetic AssociationsGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:33,951,128-33,953,284)mRNA (may differ from genome)Protein (245 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblExonPrimerGeneCardsGeneNetworkHGNCLynx
MGIPubMedUniProtKB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): MYADML
CDC HuGE Published Literature: MYADML
Positive Disease Associations: hypertension (young onset) , Lipoproteins, LDL
Related Studies:
  1. hypertension (young onset)
    Yang ,et al. 2009, Genome-wide association study of young-onset hypertension in the Han Chinese population of Taiwan, PloS one 2009 4- 5 : e5459. [PubMed 19421330]
  2. Lipoproteins, LDL
    , , . [PubMed 0]

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 12.01 RPKM in Testis
Total median expression: 12.01 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -180.73442-0.409 Picture PostScript Text
3' UTR -261.03977-0.267 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008253 - Marvel
IPR021128 - MARVEL-like_dom

Pfam Domains:
PF01284 - Membrane-associating domain

ModBase Predicted Comparative 3D Structure on Q53R84
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC031088 - Homo sapiens myeloid-associated differentiation marker-like, mRNA (cDNA clone IMAGE:5297847).
AK057470 - Homo sapiens cDNA FLJ32908 fis, clone TESTI2005860, moderately similar to MYELOID UPREGULATED PROTEIN.
JD328009 - Sequence 309033 from Patent EP1572962.
JD185533 - Sequence 166557 from Patent EP1572962.
JD523238 - Sequence 504262 from Patent EP1572962.
JD172937 - Sequence 153961 from Patent EP1572962.
BC038980 - Homo sapiens myeloid-associated differentiation marker-like, mRNA (cDNA clone IMAGE:5742332).
JD344428 - Sequence 325452 from Patent EP1572962.
JD298336 - Sequence 279360 from Patent EP1572962.
JD127282 - Sequence 108306 from Patent EP1572962.
JD506649 - Sequence 487673 from Patent EP1572962.
JD347607 - Sequence 328631 from Patent EP1572962.
JD189647 - Sequence 170671 from Patent EP1572962.
JD467347 - Sequence 448371 from Patent EP1572962.
JD097553 - Sequence 78577 from Patent EP1572962.
JD484008 - Sequence 465032 from Patent EP1572962.
JD392542 - Sequence 373566 from Patent EP1572962.
JD391563 - Sequence 372587 from Patent EP1572962.
JD256265 - Sequence 237289 from Patent EP1572962.
JD299785 - Sequence 280809 from Patent EP1572962.
JD528141 - Sequence 509165 from Patent EP1572962.
JD556608 - Sequence 537632 from Patent EP1572962.
JD500997 - Sequence 482021 from Patent EP1572962.
JD253563 - Sequence 234587 from Patent EP1572962.
JD131106 - Sequence 112130 from Patent EP1572962.
JD153916 - Sequence 134940 from Patent EP1572962.
JD133393 - Sequence 114417 from Patent EP1572962.
JD300084 - Sequence 281108 from Patent EP1572962.
JD545353 - Sequence 526377 from Patent EP1572962.
JD180405 - Sequence 161429 from Patent EP1572962.
JD293796 - Sequence 274820 from Patent EP1572962.
JD390245 - Sequence 371269 from Patent EP1572962.
JD273856 - Sequence 254880 from Patent EP1572962.
JD550986 - Sequence 532010 from Patent EP1572962.
JD146285 - Sequence 127309 from Patent EP1572962.
JD227112 - Sequence 208136 from Patent EP1572962.
JD323734 - Sequence 304758 from Patent EP1572962.
JD484927 - Sequence 465951 from Patent EP1572962.
JD290122 - Sequence 271146 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: NR_003143, Q53R84, Q53R84_HUMAN, tmp_locus_39
UCSC ID: uc002rpb.3
RefSeq Accession: NR_003143
Protein: Q53R84

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NR_003143.2
exon count: 1CDS single in 3' UTR: no RNA size: 2172
ORF size: 738CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1415.00frame shift in genome: no % Coverage: 99.31
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.