Description: Homo sapiens CD84 molecule (CD84), transcript variant 1, mRNA. RefSeq Summary (NM_001184879): This gene encodes a membrane glycoprotein that is a member of the signaling lymphocyte activation molecule (SLAM) family. This family forms a subset of the larger CD2 cell-surface receptor Ig superfamily. The encoded protein is a homophilic adhesion molecule that is expressed in numerous immune cells types and is involved in regulating receptor-mediated signaling in those cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]. Transcript (Including UTRs) Position: hg19 chr1:160,510,884-160,549,306 Size: 38,423 Total Exon Count: 8 Strand: - Coding Region Position: hg19 chr1:160,518,046-160,549,227 Size: 31,182 Coding Exon Count: 8
ID:SLAF5_HUMAN DESCRIPTION: RecName: Full=SLAM family member 5; AltName: Full=Cell surface antigen MAX.3; AltName: Full=Hly9-beta; AltName: Full=Leukocyte differentiation antigen CD84; AltName: Full=Signaling lymphocytic activation molecule 5; AltName: CD_antigen=CD84; Flags: Precursor; FUNCTION: Plays a role as adhesion receptor functioning by homophilic interactions and by clustering. Recruits SH2 domain- containing proteins SH2D1A/SAP. Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seen be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A/SAP-dependent pathway. May serve as a marker for hematopoietic progenitor cells. SUBUNIT: Homodimer; via its extracellular domain. Forms a head to tail dimer with a CD48 molecule from another cell. Interacts with SH2 domain-containing proteins SH2D1A/SAP and SH2D1B/hEAT-2. Interacts with tyrosine-protein phosphatases PTPN6 and PTPN11 via its phosphorylated cytoplasmic domain, and this interaction is blocked by SH2D1A. SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Predominantly expressed in hematopoietic tissues, such as lymph node, spleen and peripheral leukocytes. Expressed in macrophages, B-cells, monocytes, platelets, thymocytes, T-cells and dendritic cells. Highly expressed in memory T-cells. DEVELOPMENTAL STAGE: Expression is slightly increased in naive B- cells after the first dividion. By contrast, expression on memory B-cells decreased with each successive division. DOMAIN: ITSM (immunoreceptor tyrosine-based switch motif) motif is a cytoplasmic motif which may bind SH2D1A. PTM: Phosphorylated by tyrosine-protein kinase LCK on tyrosine residues following ligation induced by agonist monoclonal antibody. The association with SH2D1A/SAP is dependent of tyrosines phosphorylation of its cytoplasmic domain Phosphorylated on Tyr-296 and Tyr-316 following platelet aggregation. PTM: N-glycosylated. SIMILARITY: Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UIB8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0042802 identical protein binding
Biological Process: GO:0002250 adaptive immune response GO:0002376 immune system process GO:0006952 defense response GO:0007155 cell adhesion GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0032685 negative regulation of granulocyte macrophage colony-stimulating factor production GO:0032701 negative regulation of interleukin-18 production GO:0033004 negative regulation of mast cell activation GO:0043305 negative regulation of mast cell degranulation GO:0045087 innate immune response GO:0050900 leukocyte migration GO:2001256 regulation of store-operated calcium entry
US Server
