Description: Homo sapiens family with sequence similarity 188, member A (MINDY3), mRNA. RefSeq Summary (NM_024948): The protein encoded by this gene contains a caspase-associated recruitment domain and may function in apoptosis. It has been identified as a tumor suppressor in lung and gastric cancers, and a polymorphism in the gene may be associated with gastric cancer risk. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]. Transcript (Including UTRs) Position: hg19 chr10:15,820,175-15,902,519 Size: 82,345 Total Exon Count: 15 Strand: - Coding Region Position: hg19 chr10:15,820,991-15,902,298 Size: 81,308 Coding Exon Count: 15
ID:F188A_HUMAN DESCRIPTION: RecName: Full=Protein FAM188A; AltName: Full=Dermal papilla-derived protein 5; AltName: Full=Protein CARP; FUNCTION: May have pro-apoptotic function. Overexpression significantly inhibits cell proliferation in several tumor cell lines. INTERACTION: Q92905:COPS5; NbExp=3; IntAct=EBI-724928, EBI-594661; SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Highly expressed in heart, skeletal muscle, and kidney, with weak expression in liver and brain. SIMILARITY: Belongs to the FAM188 family. CAUTION: Was named CARP for 'CARD domain-containing protein' by PubMed:12054670. However, no CARD domain is detected by any prediction tool. SEQUENCE CAUTION: Sequence=AAG43159.1; Type=Erroneous initiation; Sequence=AAH61585.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=AAQ13660.1; Type=Frameshift; Positions=111; Sequence=CAI13817.1; Type=Erroneous gene model prediction; Sequence=CAI13818.1; Type=Erroneous gene model prediction; Sequence=CAI13819.1; Type=Erroneous gene model prediction; Sequence=EAW86233.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H8M7
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
