Human Gene TBC1D3C (uc002hlk.2) Description and Page Index
Description: Homo sapiens TBC1 domain family, member 3C (TBC1D3C), mRNA. RefSeq Summary (NM_001001418): This gene represents one of a cluster of related genes found on chromosome 17. The proteins encoded by this gene family contain a TBC (Tre-2, Bub2p, and Cdc16p) domain and may be involved in GTPase signaling and vesicle trafficking. [provided by RefSeq, Apr 2014]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AK313329.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on expression ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chr17:34,581,085-34,592,032 Size: 10,948 Total Exon Count: 14 Strand: - Coding Region Position: hg19 chr17:34,581,400-34,590,454 Size: 9,055 Coding Exon Count: 13
ID:TBC3C_HUMAN DESCRIPTION: RecName: Full=TBC1 domain family member 3C; FUNCTION: Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity). TISSUE SPECIFICITY: Expressed in pancreas, thymus and testis. SIMILARITY: Contains 1 Rab-GAP TBC domain.
Common Gene Haplotype Alleles
Press "+" in the title bar above to open this section.
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Highest median expression: 1.50 RPKM in Testis
Total median expression: 10.41 RPKM
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6IPX1
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.