Human Gene STRC (uc001zsr.1) Description and Page Index
  Description: Homo sapiens stereocilin (STRC), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr15:44,006,787-44,010,016 Size: 3,230 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr15:44,007,054-44,009,858 Size: 2,805 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
Other NamesGeneReviewsModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:44,006,787-44,010,016)mRNA (may differ from genome)Protein (649 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaCGAPEnsembl
Entrez GeneExonPrimerGeneCardsH-INVHGNCLynx
MGIOMIMPubMedStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: H7C2Q6_HUMAN
DESCRIPTION: SubName: Full=Stereocilin; Flags: Fragment;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  MalaCards Disease Associations
  MalaCards Gene Search: STRC
Diseases sorted by gene-association score: deafness, autosomal recessive 16* (928), deafness, autosomal dominant 16* (400), nonsyndromic hearing loss and deafness* (163), nonsyndromic deafness* (105), deafness-infertility syndrome* (102), dfnb16 nonsyndromic hearing loss and deafness* (100), catsper-related male infertility* (71), autosomal recessive non-syndromic sensorineural deafness type dfnb* (65), autosomal dominant nonsyndromic deafness 6 (9), autosomal recessive nonsyndromic deafness 8 (8), deafness, autosomal dominant 9 (7), deafness, autosomal dominant 13 (7), auditory system disease (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1.44 RPKM in Brain - Cerebellum
Total median expression: 8.52 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -52.87158-0.335 Picture PostScript Text
3' UTR -67.70267-0.254 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026061 - Stereocilin
IPR026664 - Stereocilin_related

ModBase Predicted Comparative 3D Structure on H7C2Q6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Descriptions from all associated GenBank mRNAs
  BC129932 - Homo sapiens stereocilin, mRNA (cDNA clone IMAGE:40070700), complete cds.
AK296993 - Homo sapiens cDNA FLJ58544 complete cds, highly similar to Stereocilin precursor.
AK122814 - Homo sapiens cDNA FLJ16411 fis, clone BRACE2016362.
AK308370 - Homo sapiens cDNA, FLJ98318.

-  Other Names for This Gene
  Alternate Gene Symbols: AK122814, H7C2Q6, H7C2Q6_HUMAN, NM_153700, NP_714544
UCSC ID: uc001zsr.1
Representative RNA: AK122814
Protein: H7C2Q6

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene STRC:
catsper-mi (CATSPER-Related Male Infertility)
deafness-overview (Hereditary Hearing Loss and Deafness Overview)

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AK122814.1
exon count: 3CDS single in 3' UTR: no RNA size: 2259
ORF size: 1950CDS single in intron: no Alignment % ID: 99.96
txCdsPredict score: 4100.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 2
has end codon: yes retained intron: yes # AT/AC introns 0
selenocysteine: no end bleed into intron: 306# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.