Human Gene KLHL2 (uc011cjm.2) Description and Page Index
  Description: Homo sapiens kelch-like family member 2 (KLHL2), transcript variant 2, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr4:166,131,171-166,244,308 Size: 113,138 Total Exon Count: 15 Strand: +
Coding Region
   Position: hg19 chr4:166,131,295-166,243,212 Size: 111,918 Coding Exon Count: 15 

Page IndexSequence and LinksGenetic AssociationsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr4:166,131,171-166,244,308)mRNA (may differ from genome)Protein (597 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
ReactomeStanford SOURCEUniProtKBWikipedia

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): KLHL2
CDC HuGE Published Literature: KLHL2

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 34.99 RPKM in Brain - Nucleus accumbens (basal ganglia)
Total median expression: 559.88 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -30.80124-0.248 Picture PostScript Text
3' UTR -253.021096-0.231 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00651 - BTB/POZ domain
PF01344 - Kelch motif
PF07646 - Kelch motif
PF07707 - BTB And C-terminal Kelch
PF13415 - Galactose oxidase, central domain
PF13964 - Kelch motif

SCOP Domains:
63825 - YWTD domain
101898 - NHL repeat
50965 - Galactose oxidase, central domain
50969 - YVTN repeat-like/Quinoprotein amine dehydrogenase
50978 - WD40 repeat-like
50993 - Prolyl oligopeptidase, N-terminal domain
54695 - POZ domain

ModBase Predicted Comparative 3D Structure on O95198-2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologGenome BrowserNo orthologNo ortholog
Gene Details  Gene Details  
Gene Sorter  Gene Sorter  
   Protein Sequence  

-  Descriptions from all associated GenBank mRNAs
  BC022503 - Homo sapiens kelch-like 2, Mayven (Drosophila), mRNA (cDNA clone MGC:26455 IMAGE:4791972), complete cds.
BC036468 - Homo sapiens kelch-like 2, Mayven (Drosophila), mRNA (cDNA clone MGC:34014 IMAGE:4799622), complete cds.
AF059569 - Homo sapiens actin binding protein MAYVEN mRNA, complete cds.
AK315372 - Homo sapiens cDNA, FLJ96418, highly similar to Homo sapiens kelch-like 2, Mayven (Drosophila) (KLHL2), mRNA.
DQ893638 - Synthetic construct clone IMAGE:100006268; FLH185732.01X; RZPDo839E05148D kelch-like 2, Mayven (Drosophila) (KLHL2) gene, encodes complete protein.
DQ895588 - Synthetic construct Homo sapiens clone IMAGE:100010048; FLH185729.01L; RZPDo839E05147D kelch-like 2, Mayven (Drosophila) (KLHL2) gene, encodes complete protein.
CU690356 - Synthetic construct Homo sapiens gateway clone IMAGE:100017421 5' read KLHL2 mRNA.
KJ898398 - Synthetic construct Homo sapiens clone ccsbBroadEn_07792 KLHL2 gene, encodes complete protein.
AK294103 - Homo sapiens cDNA FLJ60237 complete cds, highly similar to Kelch-like protein 2.
BX647776 - Homo sapiens mRNA; cDNA DKFZp686O1959 (from clone DKFZp686O1959).
AK025289 - Homo sapiens cDNA: FLJ21636 fis, clone COL08259, highly similar to AF059569 Homo sapiens actin binding protein MAYVEN mRNA.
AB209727 - Homo sapiens mRNA for Kelch-like protein 2 variant protein.
AK308940 - Homo sapiens cDNA, FLJ98981.
AK294336 - Homo sapiens cDNA FLJ60241 complete cds, highly similar to Kelch-like protein 2.
JD563722 - Sequence 544746 from Patent EP1572962.
JD305321 - Sequence 286345 from Patent EP1572962.
JD301408 - Sequence 282432 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein O95198 (Reactome details) participates in the following event(s):

R-HSA-8955241 CAND1 binds cytosolic CRL E3 ubiquitin ligases
R-HSA-983157 Interaction of E3 with substrate and E2-Ub complex
R-HSA-983147 Release of E3 from polyubiquitinated substrate
R-HSA-8955289 COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes
R-HSA-8956040 COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes
R-HSA-983140 Transfer of Ub from E2 to substrate and release of E2
R-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
R-HSA-597592 Post-translational protein modification
R-HSA-983169 Class I MHC mediated antigen processing & presentation
R-HSA-392499 Metabolism of proteins
R-HSA-1280218 Adaptive Immune System
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001161521, NP_001154994, O95198-2
UCSC ID: uc011cjm.2
RefSeq Accession: NM_001161521
Protein: O95198-2, splice isoform of O95198 CCDS: CCDS54815.1, CCDS34094.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_001161521.1
exon count: 15CDS single in 3' UTR: no RNA size: 3014
ORF size: 1794CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3638.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.