Human Gene IGIP (uc003lfb.1) Description and Page Index
  Description: Homo sapiens IgA-inducing protein homolog (Bos taurus) (IGIP), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr5:139,505,521-139,508,391 Size: 2,871 Total Exon Count: 1 Strand: +
Coding Region
   Position: hg19 chr5:139,508,062-139,508,223 Size: 162 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr5:139,505,521-139,508,391)mRNA (may differ from genome)Protein (53 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
PubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=IgA-inducing protein homolog; Flags: Precursor;
FUNCTION: Enhances IgA secretion from B-cells stimulated via CD40 (By similarity).
SUBCELLULAR LOCATION: Secreted (By similarity).
CAUTION: It is uncertain whether Met-1 or Met-7 is the initiator.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 43.30 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 773.54 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -719.992541-0.283 Picture PostScript Text
3' UTR -33.20168-0.198 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on A6NJ69
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0005576 extracellular region

-  Descriptions from all associated GenBank mRNAs
  LF211012 - JP 2014500723-A/18515: Polycomb-Associated Non-Coding RNAs.
BC041380 - Homo sapiens chromosome 5 open reading frame 53, mRNA (cDNA clone IMAGE:5275203).
LF343239 - JP 2014500723-A/150742: Polycomb-Associated Non-Coding RNAs.
JD023339 - Sequence 4363 from Patent EP1572962.
JD033535 - Sequence 14559 from Patent EP1572962.
JD035968 - Sequence 16992 from Patent EP1572962.
AB073888 - Homo sapiens primary neuroblastoma cDNA, clone:Nbla02981, full insert sequence.
BC017422 - Homo sapiens chromosome 5 open reading frame 53, mRNA (cDNA clone MGC:27375 IMAGE:4688423), complete cds.
KJ904311 - Synthetic construct Homo sapiens clone ccsbBroadEn_13705 IGIP gene, encodes complete protein.
JD026792 - Sequence 7816 from Patent EP1572962.
JD035759 - Sequence 16783 from Patent EP1572962.
MA578816 - JP 2018138019-A/150742: Polycomb-Associated Non-Coding RNAs.
MA446589 - JP 2018138019-A/18515: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: A6NJ69, C5orf53, IGIP_HUMAN, NM_001007189, NP_001007190
UCSC ID: uc003lfb.1
RefSeq Accession: NM_001007189
Protein: A6NJ69 (aka IGIP_HUMAN)
CCDS: CCDS34244.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_001007189.1
exon count: 1CDS single in 3' UTR: no RNA size: 2900
ORF size: 162CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 293.00frame shift in genome: no % Coverage: 99.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.