Human Gene BCR (uc002zww.3) Description and Page Index
  Description: Homo sapiens breakpoint cluster region (BCR), transcript variant 1, mRNA.
RefSeq Summary (NM_004327): A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: hg19 chr22:23,522,552-23,660,224 Size: 137,673 Total Exon Count: 23 Strand: +
Coding Region
   Position: hg19 chr22:23,523,148-23,657,709 Size: 134,562 Coding Exon Count: 23 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr22:23,522,552-23,660,224)mRNA (may differ from genome)Protein (1271 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedReactomeStanford SOURCETreefam
UniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: BCR_HUMAN
DESCRIPTION: RecName: Full=Breakpoint cluster region protein; EC=2.7.11.1; AltName: Full=Renal carcinoma antigen NY-REN-26;
FUNCTION: GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity.
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
SUBUNIT: Homotetramer. Interacts with PDZK1. May interact with CCPG1 (By similarity). Interacts with FES/FPS, ABL1, PIK3R1 and GRB2. Interacts with HCK.
INTERACTION: Q9H2K2:TNKS2; NbExp=3; IntAct=EBI-712838, EBI-4398527;
DOMAIN: The region involved in binding to ABL1 SH2-domain is rich in serine residues and needs to be Ser/Thr phosphorylated prior to SH2 binding. This region is essential for the activation of the ABL1 tyrosine kinase and transforming potential of the chimeric BCR-ABL oncogene.
DOMAIN: The DH domain is involved in interaction with CCPG1 (By similarity).
PTM: Autophosphorylated. Phosphorylated by FES/FPS on tyrosine residues, leading to down-regulation of the BCR kinase activity. Phosphorylation at Tyr-177 by HCK is important for interaction with GRB2.
DISEASE: Note=A chromosomal aberration involving BCR is a cause of chronic myeloid leukemia. Translocation t(9;22)(q34;q11) with ABL1. The translocation produces a BCR-ABL found also in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).
SIMILARITY: Contains 1 C2 domain.
SIMILARITY: Contains 1 DH (DBL-homology) domain.
SIMILARITY: Contains 1 PH domain.
SIMILARITY: Contains 1 Rho-GAP domain.
SEQUENCE CAUTION: Sequence=BAE06073.1; Type=Erroneous initiation;
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/BCR.html";

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): BCR
CDC HuGE Published Literature: BCR
Positive Disease Associations: Blood Vessels , Body Height , depressive disorder, major; bipolar disorder , height , Hip
Related Studies:
  1. Blood Vessels
    Ramachandran S Vasan et al. BMC medical genetics 2007, Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study., BMC medical genetics. [PubMed 17903301]
    In hypothesis-generating GWAS of echocardiography, ETT and BA vascular function in a moderate-sized community-based sample, we identified several SNPs that are candidates for replication attempts and we provide a web-based GWAS resource for the research community.
  2. Body Height
    Daniel F Gudbjartsson et al. Nature genetics 2008, Many sequence variants affecting diversity of adult human height., Nature genetics. [PubMed 18391951]
  3. depressive disorder, major; bipolar disorder
    Hashimoto, R. et al. 2005, The Breakpoint Cluster Region Gene on Chromosome 22q11 is Associated with Bipolar Disorder, Biological psychiatry. 2005 May;57(10):1097-102. [PubMed 15866548]
    Our results suggest that genetic variations in the BCR gene could confer susceptibility to bipolar disorder and major depressive disorder.
           more ... click here to view the complete list

-  MalaCards Disease Associations
  MalaCards Gene Search: BCR
Diseases sorted by gene-association score: leukemia, chronic myeloid, somatic* (880), leukemia, acute lymphoblastic* (315), leukemia, acute lymphoblastic 3* (126), chronic myelocytic leukemia* (118), precursor t-cell acute lymphoblastic leukemia* (97), philadelphia-negative chronic myeloid leukemia (18), myeloid leukemia (13), chromosome 22q11.2 deletion syndrome, distal* (12), leukemia (10), chronic leukemia (9), acute lymphocytic leukemia (8), xeroderma pigmentosum, group b (7), bone marrow cancer (7), cryoglobulinemia, familial mixed (6), lymphoid leukemia (6), myeloproliferative neoplasm (6), amyotrophic lateral sclerosis 3 (6), richter's syndrome (6), chromosome 22q11.2 microduplication syndrome (5), denture stomatitis (5), 8p11 myeloproliferative syndrome (5), chronic lymphocytic leukemia (5), lymphoblastic leukemia (5), amyotrophic lateral sclerosis 9 (5), amyotrophic lateral sclerosis 7 (4), burkitt lymphoma (4), hematologic cancer (3), b-cell expansion with nfkb and t-cell anergy (3), essential thrombocythemia (2), myelofibrosis with myeloid metaplasia, somatic (2), amyotrophic lateral sclerosis 1 (1), lymphoma, non-hodgkin (1), leukemia, acute myeloid (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D004390 Chlorpyrifos
  • C488369 dasatinib
  • C097613 imatinib
  • C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
  • C498826 4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide
  • C545373 AP24534
  • D000255 Adenosine Triphosphate
  • D001564 Benzo(a)pyrene
  • D019327 Copper Sulfate
  • D003907 Dexamethasone
          more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 28.33 RPKM in Brain - Nucleus accumbens (basal ganglia)
Total median expression: 494.79 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -400.00596-0.671 Picture PostScript Text
3' UTR -987.902515-0.393 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR015123 - Bcr-Abl_oncoprot_oligo
IPR000008 - C2_Ca-dep
IPR008973 - C2_Ca/lipid-bd_dom_CaLB
IPR018029 - C2_membr_targeting
IPR000219 - DH-domain
IPR001331 - GDS_CDC24_CS
IPR011993 - PH_like_dom
IPR001849 - Pleckstrin_homology
IPR008936 - Rho_GTPase_activation_prot
IPR000198 - RhoGAP_dom

Pfam Domains:
PF00168 - C2 domain
PF00620 - RhoGAP domain
PF00621 - RhoGEF domain
PF09036 - Bcr-Abl oncoprotein oligomerisation domain

SCOP Domains:
48350 - GTPase activation domain, GAP
69036 - Bcr-Abl oncoprotein oligomerization domain
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)

Protein Data Bank (PDB) 3-D Structure
MuPIT help

1K1F
- X-ray MuPIT

2AIN
- NMR MuPIT


ModBase Predicted Comparative 3D Structure on P11274
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Ensembl   
  Protein Sequence   
  Alignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0019899 enzyme binding

Biological Process:
GO:0002692 negative regulation of cellular extravasation
GO:0003014 renal system process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007420 brain development
GO:0016310 phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030036 actin cytoskeleton organization
GO:0030336 negative regulation of cell migration
GO:0032496 response to lipopolysaccharide
GO:0035023 regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction
GO:0042472 inner ear morphogenesis
GO:0043114 regulation of vascular permeability
GO:0043314 negative regulation of neutrophil degranulation
GO:0043547 positive regulation of GTPase activity
GO:0046777 protein autophosphorylation
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048872 homeostasis of number of cells
GO:0050728 negative regulation of inflammatory response
GO:0050766 positive regulation of phagocytosis
GO:0050885 neuromuscular process controlling balance
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051171 regulation of nitrogen compound metabolic process
GO:0051726 regulation of cell cycle
GO:0060216 definitive hemopoiesis
GO:0060268 negative regulation of respiratory burst
GO:0060313 negative regulation of blood vessel remodeling
GO:0065002 intracellular protein transmembrane transport
GO:0071222 cellular response to lipopolysaccharide
GO:2000378 negative regulation of reactive oxygen species metabolic process

Cellular Component:
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0030054 cell junction
GO:0032991 macromolecular complex
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  Y00661 - Human bcr mRNA (break point cluster gene).
X02596 - Human mRNA for bcr (breakpoint cluster region) gene in Philadelphia chromosome.
BC066122 - Homo sapiens breakpoint cluster region, mRNA (cDNA clone IMAGE:30341883).
JD211267 - Sequence 192291 from Patent EP1572962.
AB209991 - Homo sapiens mRNA for BCR variant protein, clone: aj01345.
AB384354 - Synthetic construct DNA, clone: pF1KSDB0005, Homo sapiens BCR gene for breakpoint cluster region protein, complete cds, without stop codon, in Flexi system.
EU216070 - Homo sapiens BCR/ABL fusion protein isoform Y4 (BCR/ABL fusion) mRNA, complete cds.
EU216064 - Homo sapiens BCR/ABL fusion protein isoform X7 (BCR/ABL fusion) mRNA, complete cds.
EU216062 - Homo sapiens BCR/ABL fusion protein isoform X5 (BCR/ABL fusion) mRNA, complete cds.
EU216059 - Homo sapiens BCR/ABL fusion protein isoform X2 (BCR/ABL fusion) mRNA, complete cds.
EU216061 - Homo sapiens BCR/ABL fusion protein isoform X4 (BCR/ABL fusion) mRNA, complete cds.
EU216068 - Homo sapiens BCR/ABL fusion protein isoform Y2 (BCR/ABL fusion) mRNA, complete cds.
EU216067 - Homo sapiens BCR/ABL fusion protein isoform Y1 (BCR/ABL fusion) mRNA, complete cds.
EU216065 - Homo sapiens BCR/ABL fusion protein isoform X8 (BCR/ABL fusion) mRNA, complete cds.
AM491362 - Homo sapiens partial mRNA for bcr-abl1 e6a2 chimeric protein.
X14676 - Human bcr-abl mRNA fragment (clone 10b).
AJ298916 - Homo sapiens partial mRNA for BCR/FGFR1 chimaeric fusion protein.
HQ622706 - Homo sapiens BCR-ABL1 e8a2 variant (BCR-ABL1) mRNA, partial cds.
DQ912588 - Homo sapiens BCR/ABL fusion protein e1a5 (BCR/ABL fusion) mRNA, partial cds, alternatively spliced.
M17542 - Human bcr/abl protein gene (product of translocation t(22q11; 9q34)), exons 1 and 2.
X14677 - Human bcr-abl mRNA 5' fragment (clone 8a).
X14675 - Human bcr-abl mRNA 5' fragment (clone 3c).
AK303241 - Homo sapiens cDNA FLJ58654 complete cds, highly similar to Breakpoint cluster region protein (EC 2.7.11.1).
AK128501 - Homo sapiens cDNA FLJ46653 fis, clone TRACH3005173.
DQ912589 - Homo sapiens BCR/ABL fusion protein e13a5 (BCR/ABL fusion) mRNA, partial cds, alternatively spliced.
DQ912590 - Homo sapiens BCR/ABL fusion protein e14a5 (BCR/ABL fusion) mRNA, partial cds, alternatively spliced.
M64437 - Human BCR mRNA, 5' end.
JD443520 - Sequence 424544 from Patent EP1572962.
JC506674 - Sequence 42 from Patent EP2733220.
JC737786 - Sequence 42 from Patent WO2014075939.
JC506688 - Sequence 56 from Patent EP2733220.
JC737800 - Sequence 56 from Patent WO2014075939.
JC506666 - Sequence 34 from Patent EP2733220.
JC737778 - Sequence 34 from Patent WO2014075939.
JC506661 - Sequence 29 from Patent EP2733220.
JC737773 - Sequence 29 from Patent WO2014075939.
JD406875 - Sequence 387899 from Patent EP1572962.
JD461506 - Sequence 442530 from Patent EP1572962.
JD406253 - Sequence 387277 from Patent EP1572962.
JD208476 - Sequence 189500 from Patent EP1572962.
X06418 - Human bcr-abl mRNA of acute lymphocytic leukaemia (ALL) patients.
EU216072 - Homo sapiens BCR/ABL fusion protein isoform Y6 (BCR/ABL fusion) mRNA, complete cds.
EU216058 - Homo sapiens BCR/ABL fusion protein isoform X1 (BCR/ABL fusion) mRNA, complete cds.
EU216063 - Homo sapiens BCR/ABL fusion protein isoform X6 (BCR/ABL fusion) mRNA, complete cds.
EU216069 - Homo sapiens BCR/ABL fusion protein isoform Y3 (BCR/ABL fusion) mRNA, complete cds.
M19730 - Human acute lymphocytic leukemia (ALL) BCR-ABL mRNA encoding P185-ALL-ABL protein.
DQ898313 - Homo sapiens isolate e1a4 BCR/ABL fusion protein (BCR/ABL fusion) mRNA, partial cds, alternatively spliced.
S72479 - BCR...ABL {e1/a3 junction, translocation breakpoint} [human, Japanese ALL patient 3, bone marow, mononuclear cells, mRNA Mutant, 3 genes, 131 nt].
AF251769 - Homo sapiens bcr/abl e1-a3 chimeric fusion protein (BCR/ABLe1-a3) mRNA, partial cds.
AB742170 - Homo sapiens mRNA for BCR/FGFR1 chimera protein, partial cds.
AY536245 - Homo sapiens isolate BCRcml2L1I072001 breakpoint cluster region protein (BCR) mRNA, partial cds.
AY536247 - Homo sapiens isolate BCRcml2k10I072001 breakpoint cluster region protein (BCR) mRNA, partial cds.
AY536248 - Homo sapiens isolate BCRall115I012001 breakpoint cluster region protein (BCR) mRNA, partial cds.
AY536250 - Homo sapiens isolate BCRallcl2frB012001 breakpoint cluster region protein (BCR) mRNA, partial cds.
AY533677 - Homo sapiens BCR mRNA, partial cds.
AY536246 - Homo sapiens isolate BCRCML2K191I072001 breakpoint cluster region protein (BCR) mRNA, partial cds.
AK024483 - Homo sapiens mRNA for FLJ00077 protein, partial cds.
BC169208 - Synthetic construct Homo sapiens clone IMAGE:9093269 breakpoint cluster region isoform 1 (BCR) gene, partial cds.
KU234180 - Homo sapiens BCR-ABL1 fusion protein mRNA, partial cds.
AB742171 - Homo sapiens mRNA for FGFR1/BCR chimera protein, partial cds.
AJ298917 - Homo sapiens partial mRNA for FGFR1/BCR chimaeric fusion peptide.
AB069693 - Homo sapiens mRNA for bcr/abl e8a2 fusion protein, partial cds.
EU154998 - Homo sapiens BCR/ABL e8a2 fusion protein mRNA, partial cds.
EU394717 - Homo sapiens BCR/ABL e8a2 fusion protein (BCR/ABL fusion) mRNA, exons 7, 8, a2 and partial cds.
AY536244 - Homo sapiens isolate BCRcml2K192I072001 breakpoint cluster region protein (BCR) mRNA, partial cds.
AY536249 - Homo sapiens isolate BCRcml2K23I072001 breakpoint cluster region protein (BCR) mRNA, partial cds.
E00984 - Probe detection of breakpoint cluster region.
M30829 - Human bcr/abl fusion protein mRNA, partial cds, clone K28.
M30832 - Human bcr/abl fusion protein, partial cds, clone E3.
AM491363 - Homo sapiens partial mRNA for bcr-abl1 e19a2 chimeric protein.
EU236680 - Homo sapiens BCR/ABL b3a3 fusion protein (BCR/ABL fusion) mRNA, partial cds.
EU394718 - Homo sapiens BCR/ABL e14a2 fusion protein (BCR/ABL fusion) mRNA, exons 12 through 14, a2, a3, a2 and partial cds.
AF192533 - Homo sapiens BCR-ABL fusion protein (BCR-ABL fusion) mRNA, partial cds.
AY043457 - Homo sapiens BCR-ABL fusion protein (BCR-ABL fusion) mRNA, partial cds.
AF321981 - Homo sapiens BCR-ABL fusion transcript e15a2 mRNA sequence.
DQ898314 - Homo sapiens isolate e13a4 BCR/ABL fusion protein (BCR/ABL fusion) mRNA, partial cds, alternatively spliced.
DQ898315 - Homo sapiens isolate e14a4 BCR/ABL fusion protein (BCR/ABL fusion) mRNA, partial cds, alternatively spliced.
S72478 - BCR...ABL {b3/a3 junction, translocation breakpoint} [human, Japanese CML patient 1 and ALL patient 2, peripheral blood, mononuclear cells, mRNA Mutant, 3 genes, 140 nt].
AF487522 - Homo sapiens BCRe18/ABL1e3 fusion protein (BCR/ABL fusion) mRNA, partial cds.
AK122842 - Homo sapiens cDNA FLJ16453 fis, clone BRAWH3003019, highly similar to Breakpoint cluster region protein (EC 2.7.1.-).
BC031568 - Homo sapiens breakpoint cluster region, mRNA (cDNA clone IMAGE:5192593), with apparent retained intron.
EU394716 - Homo sapiens BCR/ABL e18-int1b-a2 fusion protein (BCR/ABL fusion) mRNA, exons, 2 and partial cds.
DL490042 - Novel nucleic acids.
AK124310 - Homo sapiens cDNA FLJ42318 fis, clone TRACH2021398.
DQ576853 - Homo sapiens piRNA piR-44965, complete sequence.
JD252663 - Sequence 233687 from Patent EP1572962.
JD405642 - Sequence 386666 from Patent EP1572962.
JD384569 - Sequence 365593 from Patent EP1572962.
JD139025 - Sequence 120049 from Patent EP1572962.
JD141908 - Sequence 122932 from Patent EP1572962.
JD061380 - Sequence 42404 from Patent EP1572962.
BC063619 - Homo sapiens breakpoint cluster region, mRNA (cDNA clone IMAGE:4181461).
BC083493 - Homo sapiens breakpoint cluster region, mRNA (cDNA clone IMAGE:3868167), partial cds.
BC041705 - Homo sapiens breakpoint cluster region, mRNA (cDNA clone IMAGE:4939126).
BC127668 - Homo sapiens cDNA clone IMAGE:40128089.
BC053641 - Homo sapiens breakpoint cluster region, mRNA (cDNA clone IMAGE:4500154).
JD498487 - Sequence 479511 from Patent EP1572962.
JD462977 - Sequence 444001 from Patent EP1572962.
JD199865 - Sequence 180889 from Patent EP1572962.
JD475980 - Sequence 457004 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa05200 - Pathways in cancer
hsa05220 - Chronic myeloid leukemia

BioCarta from NCI Cancer Genome Anatomy Project
h_gleevecpathway - Inhibition of Cellular Proliferation by Gleevec
h_integrinPathway - Integrin Signaling Pathway

Reactome (by CSHL, EBI, and GO)

Protein P11274 (Reactome details) participates in the following event(s):

R-HSA-1839031 Dimerization of cytosolic FGFR1 fusion proteins
R-HSA-1839067 Phosphorylation of BCR moiety of BCR-FGFR1
R-HSA-1839095 p-BCR-pFGFR1 binds GRB2:GAB2
R-HSA-194922 GAPs inactivate Rho GTPase:GTP by hydrolysis
R-HSA-1839039 Tyrosine kinase inhibitors bind and inhibit cytosolic FGFR1 fusion dimer phosphorylation
R-HSA-1839065 Phosphorylation of cytosolic FGFR1 fusion dimers
R-HSA-1839110 p-BCR-p-FGFR1 phosphorylates GAB2
R-HSA-1839114 BCR-FGFR1:GRB2:p-GAB2 binds PIK3R1
R-HSA-1839080 Activated cytosolic FGFR1 fusions bind PIK3CA
R-HSA-1839112 Phosphorylation of STAT5 by cytosolic FGFR1 fusions
R-HSA-1839102 BCR-FGFR1 fusion:GRB2:p-GAB2:PIK3R1 binds PIK3CA
R-HSA-1839094 Activated FGFR1 mutants and fusions bind PLCG1
R-HSA-1839100 p-4Y- PLCG1 dissociates from activated FGFR1 mutants and fusions
R-HSA-1839098 Activated FGFR1 mutants and fusions phosphorylate PLCG1
R-HSA-1839091 Cytosolic FGFR1 fusion protein-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-1839107 BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3.
R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants
R-HSA-194840 Rho GTPase cycle
R-HSA-1839124 FGFR1 mutant receptor activation
R-HSA-194315 Signaling by Rho GTPases
R-HSA-5655302 Signaling by FGFR1 in disease
R-HSA-162582 Signal Transduction
R-HSA-1226099 Signaling by FGFR in disease
R-HSA-5663202 Diseases of signal transduction
R-HSA-1643685 Disease

-  Other Names for This Gene
  Alternate Gene Symbols: BCR1, BCR_HUMAN, D22S11, NM_004327, NP_004318, P11274, P78501, Q12842, Q4LE80, Q6NZI3
UCSC ID: uc002zww.3
RefSeq Accession: NM_004327
Protein: P11274 (aka BCR_HUMAN)
CCDS: CCDS13806.1, CCDS13807.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_004327.3
exon count: 23CDS single in 3' UTR: no RNA size: 6927
ORF size: 3816CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 6902.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.