Human Gene CCDC106 (uc002qlr.3) Description and Page Index
  Description: Homo sapiens coiled-coil domain containing 106 (CCDC106), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr19:56,158,954-56,164,526 Size: 5,573 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr19:56,160,413-56,164,112 Size: 3,700 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr19:56,158,954-56,164,526)mRNA (may differ from genome)Protein (280 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Coiled-coil domain-containing protein 106;
FUNCTION: Promotes the degradation of p53/TP53 protein and inhibits its transactivity.
SUBUNIT: Interacts with p53/TP53.
SUBCELLULAR LOCATION: Nucleus. Note=Colocalizes with p53/TP53.
SEQUENCE CAUTION: Sequence=AAB50227.1; Type=Erroneous termination; Positions=154; Note=Translated as Gln;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 28.78 RPKM in Brain - Nucleus accumbens (basal ganglia)
Total median expression: 545.83 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -357.50735-0.486 Picture PostScript Text
3' UTR -159.60414-0.386 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF15794 - Coiled-coil domain-containing protein 106

ModBase Predicted Comparative 3D Structure on Q9BWC9
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Cellular Component:
GO:0005634 nucleus
GO:0005829 cytosol

-  Descriptions from all associated GenBank mRNAs
  LF212082 - JP 2014500723-A/19585: Polycomb-Associated Non-Coding RNAs.
AF054984 - Homo sapiens clone 23709 mRNA sequence.
U79303 - Human clone 23882 mRNA, complete cds.
JD077359 - Sequence 58383 from Patent EP1572962.
JD217546 - Sequence 198570 from Patent EP1572962.
JD180597 - Sequence 161621 from Patent EP1572962.
AK097095 - Homo sapiens cDNA FLJ39776 fis, clone SPLEN2001626.
GU354321 - Homo sapiens coiled-coil domain-containing 106 transcript variant 1 (CCDC106) mRNA, complete cds, alternatively spliced.
GU354322 - Homo sapiens coiled-coil domain-containing 106 transcript variant 2 (CCDC106) mRNA, complete cds, alternatively spliced.
GU354323 - Homo sapiens coiled-coil domain-containing 106 transcript variant 3 (CCDC106) mRNA, complete cds, alternatively spliced.
JD129203 - Sequence 110227 from Patent EP1572962.
BC000412 - Homo sapiens coiled-coil domain containing 106, mRNA (cDNA clone MGC:8611 IMAGE:2961290), complete cds.
BC008956 - Homo sapiens coiled-coil domain containing 106, mRNA (cDNA clone MGC:3854 IMAGE:2961290), complete cds.
AY927563 - Homo sapiens mRNA sequence.
AY927628 - Homo sapiens mRNA sequence.
JD392533 - Sequence 373557 from Patent EP1572962.
JD179653 - Sequence 160677 from Patent EP1572962.
AB590944 - Synthetic construct DNA, clone: pFN21AE2174, Homo sapiens CCDC106 gene for coiled-coil domain containing 106, without stop codon, in Flexi system.
EU446599 - Synthetic construct Homo sapiens clone IMAGE:100069854; IMAGE:100011808; FLH258556.01L coiled-coil domain containing 106 (CCDC106) gene, encodes complete protein.
CU674202 - Synthetic construct Homo sapiens gateway clone IMAGE:100020673 5' read CCDC106 mRNA.
KJ898740 - Synthetic construct Homo sapiens clone ccsbBroadEn_08134 CCDC106 gene, encodes complete protein.
CR450308 - Homo sapiens full open reading frame cDNA clone RZPDo834E071D for gene ZNF581, zinc finger protein 581; complete cds; without stopcodon.
JD436510 - Sequence 417534 from Patent EP1572962.
JD451437 - Sequence 432461 from Patent EP1572962.
JD099172 - Sequence 80196 from Patent EP1572962.
JD500505 - Sequence 481529 from Patent EP1572962.
JD539822 - Sequence 520846 from Patent EP1572962.
JD416005 - Sequence 397029 from Patent EP1572962.
JD426819 - Sequence 407843 from Patent EP1572962.
MA447659 - JP 2018138019-A/19585: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: B3KUF9, CC106_HUMAN, D3K183, NM_013301, NP_037433, Q99786, Q9BWC9
UCSC ID: uc002qlr.3
RefSeq Accession: NM_013301
Protein: Q9BWC9 (aka CC106_HUMAN)
CCDS: CCDS33118.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_013301.2
exon count: 6CDS single in 3' UTR: no RNA size: 1993
ORF size: 843CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1692.00frame shift in genome: no % Coverage: 99.95
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.