Human Gene SIK3 (uc001ppy.3) Description and Page Index
  Description: Homo sapiens SIK family kinase 3 (SIK3), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr11:116,714,118-116,968,993 Size: 254,876 Total Exon Count: 24 Strand: -
Coding Region
   Position: hg19 chr11:116,717,112-116,968,957 Size: 251,846 Coding Exon Count: 23 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr11:116,714,118-116,968,993)mRNA (may differ from genome)Protein (1263 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Serine/threonine-protein kinase SIK3; EC=; AltName: Full=Salt-inducible kinase 3; Short=SIK-3; AltName: Full=Serine/threonine-protein kinase QSK;
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
COFACTOR: Magnesium.
ENZYME REGULATION: Activated by phosphorylation on Thr-163 (By similarity).
SUBUNIT: Binds to and is activated by YWHAZ when phosphorylated on Thr-163.
INTERACTION: P63104:YWHAZ; NbExp=5; IntAct=EBI-1181460, EBI-347088;
SUBCELLULAR LOCATION: Cytoplasm. Note=Locates to punctate structures within the cytoplasm on binding to YWHAZ.
PTM: Phosphorylated at Thr-163 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39.
SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
SIMILARITY: Contains 1 protein kinase domain.
SIMILARITY: Contains 1 UBA domain.
SEQUENCE CAUTION: Sequence=AAT06749.1; Type=Erroneous initiation; Sequence=BAA76843.2; Type=Erroneous initiation; Sequence=BAB14006.1; Type=Erroneous initiation;

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): SIK3
CDC HuGE Published Literature: SIK3
Positive Disease Associations: Alcohol Drinking , Lipoproteins, LDL , Pyloric Stenosis, Hypertrophic , Receptors, Transferrin , Triglycerides , Waist-Hip Ratio
Related Studies:
  1. Alcohol Drinking
    , , . [PubMed 0]
  2. Lipoproteins, LDL
    , , . [PubMed 0]
  3. Lipoproteins, LDL
    , , . [PubMed 0]
           more ... click here to view the complete list

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 22.64 RPKM in Testis
Total median expression: 502.82 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -9.4036-0.261 Picture PostScript Text
3' UTR -685.732241-0.306 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR002290 - Ser/Thr_dual-sp_kinase_dom
IPR008271 - Ser/Thr_kinase_AS
IPR015940 - UBA/transl_elong_EF1B_N_euk

Pfam Domains:
PF00069 - Protein kinase domain
PF07714 - Protein tyrosine kinase
PF14531 - Kinase-like

SCOP Domains:
56112 - Protein kinase-like (PK-like)

ModBase Predicted Comparative 3D Structure on Q9Y2K2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0046872 metal ion binding

Biological Process:
GO:0006468 protein phosphorylation
GO:0016310 phosphorylation

Cellular Component:
GO:0005737 cytoplasm

-  Descriptions from all associated GenBank mRNAs
  LF384545 - JP 2014500723-A/192048: Polycomb-Associated Non-Coding RNAs.
AB023216 - Homo sapiens mRNA for KIAA0999 protein, partial cds.
BC128511 - Homo sapiens KIAA0999 protein, mRNA (cDNA clone MGC:156923 IMAGE:40081640), complete cds.
BC128510 - Homo sapiens KIAA0999 protein, mRNA (cDNA clone MGC:156922 IMAGE:40081639), complete cds.
BC121188 - Homo sapiens KIAA0999 protein, mRNA (cDNA clone IMAGE:4396995), partial cds.
MA620122 - JP 2018138019-A/192048: Polycomb-Associated Non-Coding RNAs.
AB209327 - Homo sapiens mRNA for KIAA0999 protein variant protein.
BC086858 - Homo sapiens KIAA0999 protein, mRNA (cDNA clone IMAGE:6500609), partial cds.
LF376601 - JP 2014500723-A/184104: Polycomb-Associated Non-Coding RNAs.
BC063887 - Homo sapiens KIAA0999 protein, mRNA (cDNA clone IMAGE:30387098), complete cds.
AK022302 - Homo sapiens cDNA FLJ12240 fis, clone MAMMA1001271.
AK122838 - Homo sapiens cDNA FLJ16447 fis, clone BRAMY3010264.
JD520840 - Sequence 501864 from Patent EP1572962.
JD235701 - Sequence 216725 from Patent EP1572962.
JD379926 - Sequence 360950 from Patent EP1572962.
AY598338 - Homo sapiens L19 mRNA, complete cds.
BC035583 - Homo sapiens KIAA0999 protein, mRNA (cDNA clone IMAGE:5583560), partial cds.
KJ905433 - Synthetic construct Homo sapiens clone ccsbBroadEn_15011 SIK3 gene, encodes complete protein.
KJ906089 - Synthetic construct Homo sapiens clone ccsbBroadEn_15759 SIK3 gene, encodes complete protein.
CU690120 - Synthetic construct Homo sapiens gateway clone IMAGE:100019206 5' read KIAA0999 mRNA.
LF376597 - JP 2014500723-A/184100: Polycomb-Associated Non-Coding RNAs.
LF376590 - JP 2014500723-A/184093: Polycomb-Associated Non-Coding RNAs.
LF376588 - JP 2014500723-A/184091: Polycomb-Associated Non-Coding RNAs.
LF376587 - JP 2014500723-A/184090: Polycomb-Associated Non-Coding RNAs.
LF376584 - JP 2014500723-A/184087: Polycomb-Associated Non-Coding RNAs.
MA612178 - JP 2018138019-A/184104: Polycomb-Associated Non-Coding RNAs.
MA612174 - JP 2018138019-A/184100: Polycomb-Associated Non-Coding RNAs.
MA612167 - JP 2018138019-A/184093: Polycomb-Associated Non-Coding RNAs.
MA612165 - JP 2018138019-A/184091: Polycomb-Associated Non-Coding RNAs.
MA612164 - JP 2018138019-A/184090: Polycomb-Associated Non-Coding RNAs.
MA612161 - JP 2018138019-A/184087: Polycomb-Associated Non-Coding RNAs.
LF376578 - JP 2014500723-A/184081: Polycomb-Associated Non-Coding RNAs.
MA612155 - JP 2018138019-A/184081: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: KIAA0999, L19, NM_025164, NP_079440, Q59FY2, Q5M9N1, Q6P3R6, Q8IYM8, Q9HA50, Q9Y2K2, QSK, SIK3_HUMAN
UCSC ID: uc001ppy.3
RefSeq Accession: NM_025164
Protein: Q9Y2K2 (aka SIK3_HUMAN)
CCDS: CCDS8379.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_025164.3
exon count: 24CDS single in 3' UTR: no RNA size: 6072
ORF size: 3792CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 7617.00frame shift in genome: no % Coverage: 99.95
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.