ID:SIK3_HUMAN DESCRIPTION: RecName: Full=Serine/threonine-protein kinase SIK3; EC=184.108.40.206; AltName: Full=Salt-inducible kinase 3; Short=SIK-3; AltName: Full=Serine/threonine-protein kinase QSK; CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. COFACTOR: Magnesium. ENZYME REGULATION: Activated by phosphorylation on Thr-163 (By similarity). SUBUNIT: Binds to and is activated by YWHAZ when phosphorylated on Thr-163. INTERACTION: P63104:YWHAZ; NbExp=5; IntAct=EBI-1181460, EBI-347088; SUBCELLULAR LOCATION: Cytoplasm. Note=Locates to punctate structures within the cytoplasm on binding to YWHAZ. PTM: Phosphorylated at Thr-163 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. SIMILARITY: Contains 1 protein kinase domain. SIMILARITY: Contains 1 UBA domain. SEQUENCE CAUTION: Sequence=AAT06749.1; Type=Erroneous initiation; Sequence=BAA76843.2; Type=Erroneous initiation; Sequence=BAB14006.1; Type=Erroneous initiation;
Genetic Association Studies of Complex Diseases and Disorders
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 56112 - Protein kinase-like (PK-like)
ModBase Predicted Comparative 3D Structure on Q9Y2K2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.