ID:LHPP_HUMAN DESCRIPTION: RecName: Full=Phospholysine phosphohistidine inorganic pyrophosphate phosphatase; Short=hLHPP; EC=3.1.3.-; EC=18.104.22.168; FUNCTION: Phosphatase that hydrolyzes imidodiphosphate, 3- phosphohistidine and 6-phospholysine. Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency (By similarity). CATALYTIC ACTIVITY: Diphosphate + H(2)O = 2 phosphate. COFACTOR: Binds 1 magnesium ion per subunit. BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 7.0 for PNP, and 5.5 for PPi; SUBUNIT: Homodimer. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. TISSUE SPECIFICITY: Expressed in brain, and at lower levels in liver and kidney. Detected in thyroid (at protein level). Expressed in liver, kidney and moderately in brain. SIMILARITY: Belongs to the HAD-like hydrolase superfamily.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): LHPP CDC HuGE Published Literature: LHPP Positive Disease Associations: Cholesterol
, Hemoglobins Related Studies:
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H008
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.