Human Gene LHPP (uc001lhs.2) Description and Page Index
  Description: Homo sapiens phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr10:126,150,341-126,302,710 Size: 152,370 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chr10:126,150,432-126,301,929 Size: 151,498 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr10:126,150,341-126,302,710)mRNA (may differ from genome)Protein (270 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedReactomeStanford SOURCETreefam

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Phospholysine phosphohistidine inorganic pyrophosphate phosphatase; Short=hLHPP; EC=3.1.3.-; EC=;
FUNCTION: Phosphatase that hydrolyzes imidodiphosphate, 3- phosphohistidine and 6-phospholysine. Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency (By similarity).
CATALYTIC ACTIVITY: Diphosphate + H(2)O = 2 phosphate.
COFACTOR: Binds 1 magnesium ion per subunit.
BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 7.0 for PNP, and 5.5 for PPi;
SUBUNIT: Homodimer.
TISSUE SPECIFICITY: Expressed in brain, and at lower levels in liver and kidney. Detected in thyroid (at protein level). Expressed in liver, kidney and moderately in brain.
SIMILARITY: Belongs to the HAD-like hydrolase superfamily.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): LHPP
CDC HuGE Published Literature: LHPP
Positive Disease Associations: Cholesterol , Hemoglobins
Related Studies:
  1. Cholesterol
    , , . [PubMed 0]
  2. Hemoglobins
    , , . [PubMed 0]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 130.52 RPKM in Brain - Spinal cord (cervical c-1)
Total median expression: 821.22 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -49.3091-0.542 Picture PostScript Text
3' UTR -262.10781-0.336 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR023214 - HAD-like_dom
IPR006357 - HAD-SF_hydro_IIA
IPR006355 - HAD-SF_hydro_IIA_hyp2
IPR023215 - NPhePase-like_dom

Pfam Domains:
PF00702 - haloacid dehalogenase-like hydrolase
PF13242 - HAD-hyrolase-like
PF13344 - Haloacid dehalogenase-like hydrolase
PF13419 - Haloacid dehalogenase-like hydrolase

SCOP Domains:
56784 - HAD-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help

- X-ray MuPIT

ModBase Predicted Comparative 3D Structure on Q9H008
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details  Gene Details 
Gene SorterGene Sorter  Gene Sorter 
 RGDEnsembl WormBase 
 Protein SequenceProtein Sequence Protein Sequence 
 AlignmentAlignment Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000287 magnesium ion binding
GO:0004427 inorganic diphosphatase activity
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0101006 protein histidine phosphatase activity

Biological Process:
GO:0006470 protein dephosphorylation
GO:0006796 phosphate-containing compound metabolic process
GO:0009168 purine ribonucleoside monophosphate biosynthetic process
GO:0016311 dephosphorylation

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016607 nuclear speck

-  Descriptions from all associated GenBank mRNAs
  BC113629 - Homo sapiens phospholysine phosphohistidine inorganic pyrophosphate phosphatase, mRNA (cDNA clone MGC:142189 IMAGE:8322681), complete cds.
BC113631 - Homo sapiens phospholysine phosphohistidine inorganic pyrophosphate phosphatase, mRNA (cDNA clone MGC:142191 IMAGE:8322683), complete cds.
BC110344 - Homo sapiens phospholysine phosphohistidine inorganic pyrophosphate phosphatase, mRNA (cDNA clone MGC:117251 IMAGE:5762731), complete cds.
BC073172 - Homo sapiens phospholysine phosphohistidine inorganic pyrophosphate phosphatase, mRNA (cDNA clone IMAGE:6186909), partial cds.
AB049629 - Homo sapiens lhpp mRNA for phospholysine phosphohistidine inorganic pyrophosphate phosphatase, complete cds.
AK055532 - Homo sapiens cDNA FLJ30970 fis, clone HEART2000444, highly similar to Homo sapiens phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP), mRNA.
BC007324 - Homo sapiens phospholysine phosphohistidine inorganic pyrophosphate phosphatase, mRNA (cDNA clone IMAGE:3640409), partial cds.
HQ258160 - Synthetic construct Homo sapiens clone IMAGE:100072469 phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP) gene, encodes complete protein.
KJ899432 - Synthetic construct Homo sapiens clone ccsbBroadEn_08826 LHPP gene, encodes complete protein.
KJ899431 - Synthetic construct Homo sapiens clone ccsbBroadEn_08825 LHPP gene, encodes complete protein.
EF151005 - Homo sapiens LHPP mRNA, complete sequence.
JD124867 - Sequence 105891 from Patent EP1572962.
JD392836 - Sequence 373860 from Patent EP1572962.
JD365777 - Sequence 346801 from Patent EP1572962.
JD536735 - Sequence 517759 from Patent EP1572962.
JD460202 - Sequence 441226 from Patent EP1572962.
JD148903 - Sequence 129927 from Patent EP1572962.
JD115922 - Sequence 96946 from Patent EP1572962.
JD392836 - Sequence 373860 from Patent EP1572962.
JD123364 - Sequence 104388 from Patent EP1572962.
JD322594 - Sequence 303618 from Patent EP1572962.
JD157279 - Sequence 138303 from Patent EP1572962.
JD361981 - Sequence 343005 from Patent EP1572962.
JD263877 - Sequence 244901 from Patent EP1572962.
JD104757 - Sequence 85781 from Patent EP1572962.
JD422994 - Sequence 404018 from Patent EP1572962.
JD187980 - Sequence 169004 from Patent EP1572962.
JD545053 - Sequence 526077 from Patent EP1572962.
JD464388 - Sequence 445412 from Patent EP1572962.
JD519905 - Sequence 500929 from Patent EP1572962.
JD276931 - Sequence 257955 from Patent EP1572962.
JD453736 - Sequence 434760 from Patent EP1572962.
JD183503 - Sequence 164527 from Patent EP1572962.
JD270365 - Sequence 251389 from Patent EP1572962.
JD511015 - Sequence 492039 from Patent EP1572962.
JD457252 - Sequence 438276 from Patent EP1572962.
JD121697 - Sequence 102721 from Patent EP1572962.
JD336033 - Sequence 317057 from Patent EP1572962.
JD077242 - Sequence 58266 from Patent EP1572962.
JD445624 - Sequence 426648 from Patent EP1572962.
JD478820 - Sequence 459844 from Patent EP1572962.
JD040330 - Sequence 21354 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa00190 - Oxidative phosphorylation

Reactome (by CSHL, EBI, and GO)

Protein Q9H008 (Reactome details) participates in the following event(s):

R-HSA-6788912 LHPP:Mg2+ dimer hydrolyses PPi
R-HSA-73817 Purine ribonucleoside monophosphate biosynthesis
R-HSA-8956320 Nucleobase biosynthesis
R-HSA-15869 Metabolism of nucleotides
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: B3KP20, LHPP_HUMAN, NM_022126, NP_071409, Q2TBE9, Q5VUV9, Q5VUW0, Q9H008
UCSC ID: uc001lhs.2
RefSeq Accession: NM_022126
Protein: Q9H008 (aka LHPP_HUMAN)
CCDS: CCDS7640.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_022126.3
exon count: 7CDS single in 3' UTR: no RNA size: 1703
ORF size: 813CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1826.00frame shift in genome: no % Coverage: 98.94
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.